Design and simulation of a wireframe DNA origami nanoactuator

• Published in: The Journal of chemical physics Vol. 161; no. 4
• Main Authors: Mogheiseh, Maryam, Hasanzadeh Ghasemi, Reza
• Format: Journal Article
• Language: English
• Published: United States 28.07.2024
• Subjects: DNA - chemistry; Nanostructures - chemistry; Nanotechnology - methods; Nucleic Acid Conformation; Temperature
• ISSN: 1089-7690
• DOI: 10.1063/5.0214313

This paper explores the use of deoxyribonucleic acid (DNA) origami structures as nanorobot components. Investigating the functional properties of DNA origami structures can facilitate the fabrication of DNA origami-based nanorobots. The wireframe structure stands out as one of the most interesting DNA origami structures. Hence, the present study aims to employ these structures to create DNA origami nanoactuators. The research delves into the design of DNA origami structures with the aim of opening under specific temperature conditions. Short DNA strands (staples) are one of the crucial parts of DNA origami structures, and the appropriate design of these strands can lead to the creation of structures with different properties. Thus, the components of the DNA origami nanoactuator are tailored to enable intentional opening at specific temperatures while maintaining stability at lower temperatures. This structural modification showcases the functional property of the DNA origami structure. The engineered DNA origami nanoactuator holds potential applications in medicine. By carrying drugs under specific temperature conditions and releasing them under different temperature conditions, it can serve as a platform for smart drug delivery purposes.