Adjuvant treatment with anti-PD-1 in acral melanoma: A nationwide study

• Published in: International journal of cancer Vol. 155; no. 8; pp. 1455 - 1465
• Main Authors: Bloem, Manja, van Not, Olivier J, Aarts, Maureen J B, van den Berkmortel, Franchette W P J, Blank, Christian U, Blokx, Willeke A M, Boers-Sonderen, Marye J, Bonenkamp, Johannes J, de Groot, Jan-Willem B, Haanen, John B, Hospers, Geke A P, Kapiteijn, Ellen W, de Meza, Melissa M, Piersma, Djura, van Rijn, Rozemarijn S, Stevense-den Boer, Marion A M, van der Veldt, Astrid A M, Vreugdenhil, Gerard, van den Eertwegh, Alfons J M, Suijkerbuijk, Karijn P M, Wouters, Michel W J M
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 15.10.2024
• Subjects: Adjuvant therapy; Adjuvants; Adult; Aged; Aged, 80 and over; Chemotherapy, Adjuvant - methods; Clinical outcomes; Female; Humans; Immune checkpoint inhibitors; Immune Checkpoint Inhibitors - therapeutic use; Male; Melanoma; Melanoma - drug therapy; Melanoma - genetics; Melanoma - mortality; Melanoma - pathology; Melanoma, Cutaneous Malignant; Metastases; Metastasis; Middle Aged; Mutation; Netherlands - epidemiology; Patients; Programmed Cell Death 1 Receptor - antagonists & inhibitors; Prospective Studies; Registries; Skin Neoplasms - drug therapy; Skin Neoplasms - genetics; Skin Neoplasms - mortality; Skin Neoplasms - pathology; Survival; Survival analysis; Netherlands; melanoma; acral melanoma; immune checkpoint inhibitors; adjuvant; immunotherapy

Previous studies demonstrated limited efficacy of immune checkpoint inhibitors in unresectable acral melanoma (AM); it remains unclear how this translates to the adjuvant setting. This study investigates clinical outcomes of acral compared to cutaneous melanoma (CM) patients treated with adjuvant an...