Idiosyncratic Drug-Induced Liver Injury: A 20-Year Update of the Cases Enrolled By the Spanish Dili Registry

Background Idiosyncratic drug induced liver injury (DILI) is a rare adverse drug reaction that poses major challenges to healthcare practitioners and regulatory agencies. Conclusions The pioneering prospective Spanish DILI Registry proved to be very valuable for in-depth clinical phenotyping of hepa...

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Published inClinical therapeutics Vol. 39; no. 8; p. e57
Main Authors Slim, M, Sanabria, J, Robles-Díaz, M, Medina-Cáliz, I, Sanjuán-Jiménez, R, González-Jiménez, A, Ortega, A, García-Cortés, M, Garcia-Muñoz, B, Fernandez, M.C, Castiella, A, Zapata, E, Hallal, H, Conde, I, Prieto, M, Montane, E, Morillas, R. María, Soriano, G, Roman, E, Navarro, J.M, Jimenez, M, Aldea, A, Hernández-Guerra, M, Gines, P, Blanco, S, Moreno, J.M, Romero-Gomez, M, Gomez-Dominguez, E, Andrade, R, Lucena, M.I
Format Journal Article
LanguageEnglish
Published Bridgewater Elsevier Inc 01.08.2017
Elsevier Limited
Subjects
Health care
Hepatotoxicity
Internal Medicine
Liver
Medical Education
Phenotyping
Regulatory agencies
Spain
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Summary:Background Idiosyncratic drug induced liver injury (DILI) is a rare adverse drug reaction that poses major challenges to healthcare practitioners and regulatory agencies. Conclusions The pioneering prospective Spanish DILI Registry proved to be very valuable for in-depth clinical phenotyping of hepatotoxicity, providing consistent figures in clinical characteristic outcomes and implicated...
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2017.05.177