Cooperative Iron-Brønsted Acid Catalysis: Enantioselective Hydrogenation of Quinoxalines and 2 H-1,4-Benzoxazines

Come together! A selective Fe‐catalysed enantioselective reduction of quinoxalines and benzoxazines with hydrogen is demonstrated. Key to success is the combination of a chiral Brønsted acid and a well‐defined non‐chiral Fe hydrogenation catalyst. This methodology constitutes an attractive and envir...

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Published inChemistry : a European journal Vol. 19; no. 16; pp. 4997 - 5003
Main Authors Fleischer, Steffen, Zhou, Shaolin, Werkmeister, Svenja, Junge, Kathrin, Beller, Matthias
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 15.04.2013
WILEY‐VCH Verlag
Subjects
asymmetric catalysis
enantioselectivity
hydrogenation
iron
organocatalysis
quinoxalines
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Summary:Come together! A selective Fe‐catalysed enantioselective reduction of quinoxalines and benzoxazines with hydrogen is demonstrated. Key to success is the combination of a chiral Brønsted acid and a well‐defined non‐chiral Fe hydrogenation catalyst. This methodology constitutes an attractive and environmentally favourable alternative to well‐established asymmetric hydrogenations by using precious‐metal‐based catalysts.
Bibliography:BMBF
ArticleID:CHEM201204236
ark:/67375/WNG-RZLV0DZB-J
Bundesministerium für Bildung und Forschung
istex:B898482F4F32F044B01F210C8035D269CA71A705
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201204236