The interchangeability of gabapentin 800 mg tablets: a randomized, controlled trial to establish individual bioequivalence

For some products it is advised not to switch between medicinal products from different manufacturers once treatment started, because it is believed that they are not completely interchangeable. [...]we aimed to investigate (1) the interchangeability of gabapentin 800mg tablets marketed as Neurontin...

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Bibliographic Details
Published inClinical therapeutics Vol. 37; no. 8; p. e33
Main Authors Van Bever, E, Colin, P, Van Lancker, G, Azermai, M, Delafontaine, B, Boussery, K, Swart, E.L, Chahbouni, A, Van Bocxlaer, J, Van Bortel, L
Format Journal Article
LanguageEnglish
Published Bridgewater Elsevier Inc 01.08.2015
Elsevier Limited
Subjects
Internal Medicine
Medical Education
Pharmaceutical industry
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Summary:For some products it is advised not to switch between medicinal products from different manufacturers once treatment started, because it is believed that they are not completely interchangeable. [...]we aimed to investigate (1) the interchangeability of gabapentin 800mg tablets marketed as Neurontin® and Gabasandoz® following FDA guidelines using the individual bioequivalence (IBE) approach and (2) the interchangeability in a more real-life situation by including two different batches of each product (Neurontin® & Gabasandoz®, both Batch 'A' and 'B').
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2015.05.104