Invasive candidiasis in critical care setting, updated recommendations from "Invasive Fungal Infections-Clinical Forum", Iran

Invasive candidiasis (IC) bears a high risk of morbidity and mortality in the intensive care units (ICU). With the current advances in critical care and the use of wide-spectrum antibiotics, invasive fungal infections (IFIs) and IC in particular, have turned into a growing concern in the ICU. Furthe...

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Published inWorld journal of critical care medicine Vol. 3; no. 4; pp. 102 - 112
Main Authors Elhoufi, Ashraf, Ahmadi, Arezoo, Asnaashari, Amir Mohammad Hashem, Davarpanah, Mohammad Ali, Bidgoli, Behrooz Farzanegan, Moghaddam, Omid Moradi, Torabi-Nami, Mohammad, Abbasi, Saeed, El-Sobky, Malak, Ghaziani, Ali, Jarrahzadeh, Mohammad Hossein, Shahrami, Reza, Shirazian, Farzad, Soltani, Farhad, Yazdinejad, Homeira, Zand, Farid
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 04.11.2014
Subjects
Review
Recommendations
Invasive candidiasis
Iran
IFI-clinical forum
Intensive care unit
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Summary:Invasive candidiasis (IC) bears a high risk of morbidity and mortality in the intensive care units (ICU). With the current advances in critical care and the use of wide-spectrum antibiotics, invasive fungal infections (IFIs) and IC in particular, have turned into a growing concern in the ICU. Further to blood cultures, some auxiliary laboratory tests and biomarkers are developed to enable an earlier detection of infection, however these test are neither consistently available nor validated in our setting. On the other hand, patients' clinical status and local epidemiology data may justify the empiric antifungal approach using the proper antifungal option. The clinical approach to the management of IC in febrile, non-neutropenic critically ill patients has been defined in available international guidelines; nevertheless such recommendations need to be customized when applied to our local practice. Over the past three years, Iranian experts from intensive care and infectious diseases disciplines have tried to draw a consensus on the management of IFI with a particular focus on IC in the ICU. The established IFI-clinical forum (IFI-CF), comprising the scientific leaders in the field, has recently come up with and updated recommendation on the same (June 2014). The purpose of this review is to put together literature insights and Iranian experts' opinion at the IFI-CF, to propose an updated practical overview on recommended approaches for the management of IC in the ICU.
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Correspondence to: Mohammad Torabi-Nami, MD, PhD, Assistant Professor of Neuroscience, Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Zand St., Shiraz 7134814336, Iran. torabinami@sums.ac.ir
Telephone: +98-713-2317523 Fax: +98-713-2318042
Author contributions: Elhoufi A moderated the clinical forum and contributed to literature review; other than the first author, at second order, Ahmadi A, Asnaashari AMH, Davarpanah MA, Farzanegan Bidgoli B, Moradi Moghaddam O and Torabi-Nami M equally contributed to literature review and plenary talks as well as summary of recommendations (sorted alphabetically as second-order authors); at third order, Abbasi S, El-Sobky M, Ghaziani A, Jarrahzadeh MH, Shahrami R, Shirazian F, Soltani F, Yazdinejad H and Zand F equally contributed to this consensus through inputs and critical reversion of the manuscript for important intellectual content (sorted alphabetically as third-order authors); Torabi-Nami M drafted the manuscript; Torabi-Nami M and El-Sobky M provided technical material support; all authors read and approved the final manuscript.
ISSN:2220-3141
2220-3141
DOI:10.5492/wjccm.v3.i4.102