Comfortable Lifestyle-induced Imbalance of Neuro-endocrine- immunity Network： A Possible Mechanism of Vascular Endothelial Dysfunction

• Published in: Chinese journal of integrative medicine Vol. 16; no. 1; pp. 54 - 60
• Main Author: 袁国强 贾振华 杨海涛 吴士珍 高怀林 魏聪 朱慧明 吴以岭
• Format: Journal Article
• Language: English
• Published: China 01.02.2010
• Subjects: Animals; Aorta - metabolism; Aorta - pathology; Aorta - physiopathology; Aorta - ultrastructure; Biomarkers - analysis; Biomarkers - metabolism; Cardiovascular Diseases - etiology; Cardiovascular Diseases - metabolism; Cardiovascular Diseases - pathology; Cardiovascular Diseases - physiopathology; Disease Models, Animal; Endothelins - metabolism; Endothelium, Vascular - metabolism; Endothelium, Vascular - pathology; Endothelium, Vascular - physiopathology; Immune System - metabolism; Immune System - pathology; Immune System - physiology; Male; Neuroimmunomodulation - physiology; Neurosecretory Systems - metabolism; Neurosecretory Systems - pathology; Neurosecretory Systems - physiology; Nitric Oxide - metabolism; Rats; Rats, Wistar; Sedentary Lifestyle; Syndrome; Wistar大鼠; Yin Deficiency - etiology; Yin Deficiency - metabolism; Yin Deficiency - pathology; Yin Deficiency - physiopathology; 免疫网络; 功能障碍; 可能机制; 生活习惯; 神经内分泌; 肿瘤坏死因子-α; 血管内皮功能
• ISSN: 1672-0415; 1993-0402; 1993-0402
• DOI: 10.1007/s11655-010-0054-7

Objective： To observe the changes of vascular endothelial functions and general neuroendocrine-immunity （NEI） network under the state of qi-deficiency syndrome induced by excessive idleness and to approach their internal relevance and illuminate initially the pathophysiological mechanism of vascular lesion induced by excessive idleness. Methods： A total of 100 male Wistar rats were randomly divided into the control group and the qi-deficiency syndrome model group, 50 rats in each group. The qi-deficiency syndrome model was established by feeding the animals with hyper-alimentation diet in combination with restricting movement for 10 weeks. Changes of common chemical signal molecules related to NEI and vascular endothelial functions were measured by the end of the experiment. Furthermore, their internal relevance was analyzed by the method of canonical correlation analysis. Results： The vascular endothelial structure and function were obviously injured in the model group. Compared with the control group, the chemical signal molecules, such as 5-hydroxytryptamine （5-HT）, corticosterone （CORT）, triiodothyronine （T3）, tetraiodothyronine （T4）, angiotensin Ⅱ （Ang Ⅱ）, interleukin-1 （IL-1）, and tumor necrosis factor-α （TNF-α） in peripheral blood of the model group （n=43） were changed significantly （P〈0.05 or P〈0.01）. Canonical correlation analysis showed that vascular endothelial dysfunction was correlated to the changes of these signal molecules in the NEI network. Conclusions： Comfortbased lifestyle induced not only vascular endothelial dysfunction but also an imbalance of the NEI network. Vascular endothelial dysfunction and the imbalanced NEI network interacted with each other, and an imbalance of the NEI network may be the pathophysiologic basis for the genesis and development of vascular endothelial dysfunction, even diseases of the blood vessel.