The correlation of clinical measures with the histopathological findings in nasal polyposis

• Published in: ENT updates Vol. 5; no. 1; pp. 1 - 8
• Main Authors: Altın Kule, Zeynep, Deveci, Hande Senem, Kule, Mustafa, Tülay, Erden Habeşoğlu, Somay, Adnan, Ali Okan, Gürsel
• Format: Journal Article
• Language: English
• Published: Istanbul Continuous Education and Scientific Research Association (CESRA) 01.04.2015
• ISSN: 2149-7109; 2149-6498
• DOI: 10.2399/jmu.2015001002

Objective: The aim of this study was to outline the histopathological findings of nasal polyposis and to investigate whether these findings were associated with the severity of the disease and co-existing morbidities as well as hematological parameters. Methods: Seventy-seven nasal polyposis (52 male, 25 female; mean age: 46.99±13.27 years) patients who underwent endoscopic sinus surgery between 2007 and 2011 were included in the study. Data was extracted from medical files and endoscopy scores, and Lund-Mackay Computed Tomography scores, Nasal Obstruction Symptom Evaluation (NOSE) scales, presence of allergy and asthma, and blood eosinophil levels were noted. Correlation of this data with histopathological findings (such as basement membrane thickness, goblet cell hyperplasia, subepithelial edema, submucous gland formation, eosinophilic infiltration, lymphocytic infiltration and polymorphonuclear leukocyte infiltration) was analyzed. Results: Analysis of our findings yielded that the only statistically significant finding was the correlation of eosinophilic infiltration with the blood eosinophil level (p<0.01). No other statistically significant differences were found between histopathological findings and accompanying clinical or hematological parameters under investigation. Conclusion: Results of the current study have shown that histopathological features of nasal polyposis do not exhibit correlation with the severity or extent of the disease.