New neo-Clerodanes from Tinnea antiscorbutica Welv

Three new neo-clerodanes, antiscorbuticane A, antiscorbuticane B and antiscorbuticane C, and known compounds glutinol, friedelin, 5,7-dihydroxyflavanone (pinocembrin), 5-hydroxy-3,6,7,4'-tetramethoxyflavone, 5-hydroxy-3,6,7,3',4'-pentamethoxyflavone (artemetin), 5,4'-dihydroxy-3,...

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Published inJournal of the Brazilian Chemical Society Vol. 24; no. 12; pp. 1950 - 1956
Main Authors Borges, Cristina M. P., de Mendonca, Dina I. M. D., Pinheiro, Sandra C. S., Vieira, Liliana, Mendonca, Antonio J. G., Gaspar, Jorge F., Martins, Celia, Diakanawma, Carlos, Rueff, Jose
Format Journal Article
LanguageEnglish
Portuguese
Published SAO PAULO Soc Brasileira Quimica 01.12.2013
Sociedade Brasileira de Química
Subjects
Chemistry
CHEMISTRY, MULTIDISCIPLINARY
Physical Sciences
Science & Technology
genotoxicity
APOPTOSIS
CHEMICAL-CONSTITUENTS
Tinnea antiscorbutica
DITERPENOIDS
mutagenic activity
neo-clerodanes
FLAVONOIDS
cytotoxic activity
PINOCEMBRIN
GLUTINOL
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Summary:Three new neo-clerodanes, antiscorbuticane A, antiscorbuticane B and antiscorbuticane C, and known compounds glutinol, friedelin, 5,7-dihydroxyflavanone (pinocembrin), 5-hydroxy-3,6,7,4'-tetramethoxyflavone, 5-hydroxy-3,6,7,3',4'-pentamethoxyflavone (artemetin), 5,4'-dihydroxy-3,6,7,3'-tetramethoxyflavone (penduletin) and 5,3',4'-trihydroxy-3,6,7-trimethoxyflavone (chrysosplenol D), were isolated from the methanol extract of Tinnea antiscorbutica. Antiscorbuticane B exhibited no mutagenic activity at doses of up to 250 mu g per plate (Ames test) and did not induce micronucleus formation in the V79 cell line at doses of up to 100 mu g mL(-1).
Bibliography:FCT
ISSN:0103-5053
1678-4790
1678-4790
DOI:10.5935/0103-5053.20130244