New neo-Clerodanes from Tinnea antiscorbutica Welv
Three new neo-clerodanes, antiscorbuticane A, antiscorbuticane B and antiscorbuticane C, and known compounds glutinol, friedelin, 5,7-dihydroxyflavanone (pinocembrin), 5-hydroxy-3,6,7,4'-tetramethoxyflavone, 5-hydroxy-3,6,7,3',4'-pentamethoxyflavone (artemetin), 5,4'-dihydroxy-3,...
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Published in | Journal of the Brazilian Chemical Society Vol. 24; no. 12; pp. 1950 - 1956 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English Portuguese |
Published |
SAO PAULO
Soc Brasileira Quimica
01.12.2013
Sociedade Brasileira de Química |
Subjects | |
Online Access | Get full text |
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Summary: | Three new neo-clerodanes, antiscorbuticane A, antiscorbuticane B and antiscorbuticane C, and known compounds glutinol, friedelin, 5,7-dihydroxyflavanone (pinocembrin), 5-hydroxy-3,6,7,4'-tetramethoxyflavone, 5-hydroxy-3,6,7,3',4'-pentamethoxyflavone (artemetin), 5,4'-dihydroxy-3,6,7,3'-tetramethoxyflavone (penduletin) and 5,3',4'-trihydroxy-3,6,7-trimethoxyflavone (chrysosplenol D), were isolated from the methanol extract of Tinnea antiscorbutica. Antiscorbuticane B exhibited no mutagenic activity at doses of up to 250 mu g per plate (Ames test) and did not induce micronucleus formation in the V79 cell line at doses of up to 100 mu g mL(-1). |
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Bibliography: | FCT |
ISSN: | 0103-5053 1678-4790 1678-4790 |
DOI: | 10.5935/0103-5053.20130244 |