Inhibitory and Enzyme-Kinetic Investigation of Chelerythrine and Lupeol Isolated from Zanthoxylum rhoifolium Against Krait Snake Venom Acetylcholinesterase
The in vitro activity of chelerythrine and lupeol, two metabolites isolated from Zanthoxylum rhoifolium were studied against the venom of the snake Bungarus sindanus (Elapidae). The venom, which is highly toxic to humans, consists mainly by the enzyme acetylcholinesterase (AChE). Both compounds show...
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Published in | Journal of the Brazilian Chemical Society Vol. 25; no. 1; pp. 98 - 103 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English Portuguese |
Published |
Sociedade Brasileira de Química
01.01.2014
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Subjects | |
Online Access | Get full text |
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Summary: | The in vitro activity of chelerythrine and lupeol, two metabolites isolated from Zanthoxylum rhoifolium were studied against the venom of the snake Bungarus sindanus (Elapidae). The venom, which is highly toxic to humans, consists mainly by the enzyme acetylcholinesterase (AChE). Both compounds showed activity against the venom, and the alkaloid chelerythrine presented higher activity than did triterpene lupeol. |
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ISSN: | 0103-5053 1678-4790 |
DOI: | 10.5935/0103-5053.20130274 |