Inhibitory and Enzyme-Kinetic Investigation of Chelerythrine and Lupeol Isolated from Zanthoxylum rhoifolium Against Krait Snake Venom Acetylcholinesterase

The in vitro activity of chelerythrine and lupeol, two metabolites isolated from Zanthoxylum rhoifolium were studied against the venom of the snake Bungarus sindanus (Elapidae). The venom, which is highly toxic to humans, consists mainly by the enzyme acetylcholinesterase (AChE). Both compounds show...

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Published inJournal of the Brazilian Chemical Society Vol. 25; no. 1; pp. 98 - 103
Main Authors Ahmad, Mustaq, Weber, Andréia D., Zanon, Graciane, Tavares, Luciana de C., Ilha, Vinicius, Dalcol, Ionara I., Morel, Ademir F.
Format Journal Article
LanguageEnglish
Portuguese
Published Sociedade Brasileira de Química 01.01.2014
Subjects
CHEMISTRY, MULTIDISCIPLINARY
venom of the Bungarus sindanus
lupeol
inhibition of AChE
Zanthoxylum rhoifolium
chelerythrine
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Summary:The in vitro activity of chelerythrine and lupeol, two metabolites isolated from Zanthoxylum rhoifolium were studied against the venom of the snake Bungarus sindanus (Elapidae). The venom, which is highly toxic to humans, consists mainly by the enzyme acetylcholinesterase (AChE). Both compounds showed activity against the venom, and the alkaloid chelerythrine presented higher activity than did triterpene lupeol.
ISSN:0103-5053
1678-4790
DOI:10.5935/0103-5053.20130274