What did we catch? Predictors of infection after tissue expander–based breast reconstruction in a safety-net system

• Published in: Journal of plastic, reconstructive & aesthetic surgery Vol. 96; pp. 83 - 91
• Main Authors: Obinero, Chioma G., Talanker, Michael, Green, Jackson, Paidisetty, Praneet, Nye, Jessica, Barrera, Jose E., Boyd, Alexandra, Wei, Shuyan, Parikh, Janak, Maricevich, Marco, Greives, Matthew R., Sputova, Klara, Marques, Erik
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.09.2024
• Subjects: Acellular Dermis; Adult; Body Mass Index; Breast Neoplasms - surgery; Breast reconstruction; Female; Humans; Infection; Mammaplasty - adverse effects; Mammaplasty - methods; Middle Aged; Predictors; Retrospective Studies; Risk Factors; Safety-net hospital; Safety-net Providers; Surgical Wound Infection - epidemiology; Surgical Wound Infection - etiology; Tissue expander; Tissue Expansion - adverse effects; Tissue Expansion - instrumentation; Tissue Expansion Devices - adverse effects; Infection; Tissue expander; Safety-net hospital; Breast reconstruction; Predictors
• ISSN: 1748-6815; 1878-0539; 1878-0539
• DOI: 10.1016/j.bjps.2024.07.023

Infection is a common complication following tissue expander (TE)–based breast reconstruction. Few studies have examined risk factors specifically in the unique populations encountered at safety-net hospitals. The purpose of this study was to identify predictors of TE infection at Harris Health safety-net hospitals, which serve the third most populous county in the United States. A retrospective review was performed to evaluate women over the age of 18 years who underwent TE placement at two safety-net hospitals from October 2015 to November 2022. Demographic information, medical history, operative details, and postoperative course were recorded for each individual TE. The primary outcome was TE infection, for which univariate and multivariate analysis was conducted. The secondary outcome was the time to onset of TE infection, for which a Kaplan-Meier analysis was undertaken. There were 279 patients, totaling 372 breasts, meeting the inclusion criteria. The TE infection rate was 23%. Increased body mass index (BMI), diabetes, use of acellular dermal matrix (ADM), and prolonged surgical drain use were all significantly associated with TE infection in univariate and multivariate analysis. Similarly, BMI ≥30 kg/m2, diabetes, and ADM use were also associated with earlier onset of TE infection. This study demonstrated similar TE infection rates at our safety-net hospitals compared with previously reported literature. To optimize the quality of care for patients in safety-net institutions, these risk factors must be addressed in the context of the unique challenges encountered in these settings.