Magnetic seed localization is feasible for non-palpable melanoma, Merkel cell carcinoma, and soft tissue sarcoma lesions

• Published in: European journal of surgical oncology Vol. 50; no. 10; p. 108485
• Main Authors: van der Burg, S.J.C., Kuijpers, A., Baetens, T., van Akkooi, A.C.J., Reijers, S.J.M., Wouters, M.W.J.M., Schrage, Y.M., van Houdt, W.J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2024
• Subjects: Adult; Aged; Aged, 80 and over; Carcinoma, Merkel Cell - diagnostic imaging; Carcinoma, Merkel Cell - pathology; Carcinoma, Merkel Cell - surgery; Feasibility Studies; Female; Fiducial Markers; Humans; Localization; Magnetic seeds; Male; Margins of Excision; Melanoma; Melanoma - diagnostic imaging; Melanoma - pathology; Melanoma - surgery; Middle Aged; Non-palpable; Retrospective Studies; Sarcoma - diagnostic imaging; Sarcoma - pathology; Sarcoma - surgery; Sirius Pintuition; Skin Neoplasms - diagnostic imaging; Skin Neoplasms - pathology; Skin Neoplasms - surgery; Soft tissue sarcoma; Melanoma; MSL; Soft tissue sarcoma; RSL; Sirius Pintuition; Non-palpable; MCC; CT; STS; SMN; PET/CT; ROLL; Localization; WGL; Magnetic seeds
• ISSN: 0748-7983; 1532-2157; 1532-2157
• DOI: 10.1016/j.ejso.2024.108485

Localization of non-palpable melanoma, Merkel cell carcinoma (MCC) and soft tissue sarcoma (STS) lesions can be difficult due to size, location, and obesity of patients or fibrosis due to previous treatments. Magnetic seed localization (MSL) is a common method to localize non-palpable breast lesions, but the feasibility of MSL for non-palpable melanoma, MCC and STS lesions has not yet been described. In this retrospective single center cohort study, all consecutive patients between January 2021 and October 2023 who had a resection of a non-palpable melanoma, MCC or STS lesion guided by Sirius Pintuition, a MSL technique, were included. The primary endpoint was successful lesion localization during surgery and the secondary endpoints were seed migration, negative resection margins, and complications. Seventy-nine seeds were placed for 76 lesions, which were resected during 68 surgeries in 61 patients. All lesions (100 %) were localized and resected. Median time of surgery was 44 min. No seed migration was observed. A negative resection margin was achieved for 60 (78.9 %) lesions. Clavien Dindo grade ≥2 complications occurred in 7.4 %. Magnetic seed localization with Sirius Pintuition is feasible for both non-palpable melanoma, MCC, and STS lesions.