Volume stabilization in human erythrocytes: combined effects of Ca2+-dependent potassium channels and adenylate metabolism

A mathematical model describing the possible role of Ca(2+)-dependent K+ channels and adenylate metabolism in volume stabilization of human erythrocytes was developed. The model predicts that the red blood cell volume can be stabilized either dynamically or stationary over a broad range of cell memb...

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Bibliographic Details
Published inBiophysical chemistry Vol. 80; no. 3; pp. 199 - 215
Main Authors Martinov, M V, Vitvitsky, V M, Ataullakhanov, F I
Format Journal Article
LanguageEnglish
Published Netherlands 30.08.1999
Subjects
Adenosine Monophosphate - blood
Calcium - blood
Erythrocyte Volume
Erythrocytes - cytology
Erythrocytes - metabolism
Erythrocytes - physiology
Humans
Mathematical Computing
Models, Biological
Potassium Channels - blood
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Summary:A mathematical model describing the possible role of Ca(2+)-dependent K+ channels and adenylate metabolism in volume stabilization of human erythrocytes was developed. The model predicts that the red blood cell volume can be stabilized either dynamically or stationary over a broad range of cell membrane permeabilities to cations. The dynamic stabilization results from the operation of Ca(2+)-dependent potassium channels. The erythrocyte volume changes less than 10% if the membrane permeability changes abruptly to a value in the range from half to sevenfold higher than the normal one. The stationary stabilization is achieved via controlling the adenylate metabolism. The stationary value of cell volume changes less than 10% when the membrane permeability varies from half the normal value to 15-fold higher than the normal value.
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ISSN:0301-4622
DOI:10.1016/S0301-4622(99)00079-4