The Effects of a Liquid Dentifrice Containing an Antibacterial Agent and Anti-inflammatory Agents on The Prevention of Periodontal Disease
The purpose of this clinical study was to evaluate the effects of a test liquid dentifrice containing 0.1% triclosan, 0.05% tranexamic acid and 0.05% dipotassium glycyrrhizinate on the control of dental plaque, and the prevention and/or improvement of periodontal disease in comparison with a placebo...
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| Published in | Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) Vol. 36; no. 1; pp. 215 - 222 |
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| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
JAPANESE SOCIETY OF PERIODONTOLOGY
1994
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0385-0110 1880-408X |
| DOI | 10.2329/perio.36.215 |
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| Abstract | The purpose of this clinical study was to evaluate the effects of a test liquid dentifrice containing 0.1% triclosan, 0.05% tranexamic acid and 0.05% dipotassium glycyrrhizinate on the control of dental plaque, and the prevention and/or improvement of periodontal disease in comparison with a placebo dentifrice. Subjects were 60 adults who had no serious oral and systemic disease. They were divided into two groups of equal size and performed toothbrushing twice a day for fuor weeks. The results were summarized as follows: 1) The test liquid dentifrice was significantry superior to the placebo dentifrice in improving the gingival index (P<0.01) and the plaque index P<0.01). (2) No particular side effects were observed during this clinical study. |
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| AbstractList | The purpose of this clinical study was to evaluate the effects of a test liquid dentifrice containing 0.1% triclosan, 0.05% tranexamic acid and 0.05% dipotassium glycyrrhizinate on the control of dental plaque, and the prevention and/or improvement of periodontal disease in comparison with a placebo dentifrice. Subjects were 60 adults who had no serious oral and systemic disease. They were divided into two groups of equal size and performed toothbrushing twice a day for fuor weeks. The results were summarized as follows: 1) The test liquid dentifrice was significantry superior to the placebo dentifrice in improving the gingival index (P<0.01) and the plaque index P<0.01). (2) No particular side effects were observed during this clinical study. |
| Author | TATSUMI, Junichi ICHIMURA, Koh OBARA, Toshihiko OHTSUKA, Hideharu IKEDA, Katsumi SHIMOJIMA, Takahiro KURIHARA, Noriyoshi OHISHI, Mika ANAI, Kyoichi WATANABE, Yukio NAKAGIMA, Keiji FUJITA, Kouji SUDOU, Youtarou |
| Author_xml | – sequence: 1 fullname: FUJITA, Kouji organization: Department of Periodontolgy, Meikai University School of Dentistry – sequence: 1 fullname: OHISHI, Mika organization: Department of Periodontolgy, Meikai University School of Dentistry – sequence: 1 fullname: ANAI, Kyoichi organization: Department of Periodontolgy, Meikai University School of Dentistry – sequence: 1 fullname: WATANABE, Yukio organization: Department of Periodontolgy, Meikai University School of Dentistry – sequence: 1 fullname: NAKAGIMA, Keiji organization: Department of Periodontolgy, Meikai University School of Dentistry – sequence: 1 fullname: IKEDA, Katsumi organization: Department of Periodontolgy, Meikai University School of Dentistry – sequence: 1 fullname: OHTSUKA, Hideharu organization: Department of Periodontolgy, Meikai University School of Dentistry – sequence: 1 fullname: SHIMOJIMA, Takahiro organization: Department of Periodontolgy, Meikai University School of Dentistry – sequence: 1 fullname: SUDOU, Youtarou organization: Department of Periodontolgy, Meikai University School of Dentistry – sequence: 1 fullname: KURIHARA, Noriyoshi organization: Department of Periodontolgy, Meikai University School of Dentistry – sequence: 1 fullname: TATSUMI, Junichi organization: Department of Periodontolgy, Meikai University School of Dentistry – sequence: 1 fullname: OBARA, Toshihiko organization: Department of Periodontolgy, Meikai University School of Dentistry – sequence: 1 fullname: ICHIMURA, Koh organization: Department of Periodontolgy, Meikai University School of Dentistry |
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| References | Gilbert, R.J. and Williams, P.E.O. : The oral retention and antiplaque efficacy of triclosan in human volunteers. Britt. J. Clin. Pharmacol., 23: 579-583, 1987. 山内康平, 磯部敬, 藤田拓男: 動脈硬化と補体系-グリチルリチンの補体に及ぼす影響-臨床免疫, 13: 145-152, 1981. Jenkins, S., Addy, M. and Newcombe, R.: Studies on the effect of toothpaste rins on plaque regrowth (II). Triclosan with and without zinc citrate formulations. J. Clin. periodontol., 16: 385 -387, 1989 . 佐藤重孝: 唾液の酵素学的研究: 健常者混合唾液の線溶能およびLysozyme活性ならびに齲蝕との関係. 名市大医誌, 18: 867-874, 1967. Saxton, C. A.: The effects of a dentifrice containing zinc citrate and 2, 4, 4'-trichloro-2'-hydroxydiphenyl ether. J. Periodontol., 57: 555-561, 1986. Gjermo, P. and Saxton, C. A.: Anti-bacterial dentifrices clinical data and relevance with emphasis on zinc/triclosan. J. Clin. Periodontol., 18: 468-473, 1991. 氏家高志: むし歯予防と新しい歯磨剤. 家庭科学研究, 33: 16-20, 1991. Rocha e Silva, M., Androde, S.O. and Jeixeira, R. M.: Fibrinolysis in peptone andanaphylactic shock in dog. Nature, 157: 801-802, 1946. 森本清治: 唾液の酵素学的研究: 歯槽膿漏患者混合唾液, 固有唾液の線溶能およびLysozyme活性について. 名市大医誌, 20: 118-128, 1969. 佐藤巌雄, 渡辺幸男, 下島孝裕, 小野寺修, 大沢一茂, 中島啓次, 栗橋豊, 真島徹楠公仁, 池田克已, 福地直二, 松本たまみ, 菅沼信夫, 平山豊, 亀山省司: オウバクエキス配合歯磨剤の歯周疾患予防効果に関する研究 (第2報) -オウバクエキス及び抗炎症剤配合歯磨剤の臨床効果について-. 日歯周誌, 30: 887-900, 1988. Lindhe, J., Rosling, B., Socransky, S.S. and Volpe, A. R.: The effect of a triclosan-containing dentifrice on established plaque and gingivitis. J. Clin. Periodontol., 20: 327-334, 1993. Morn, J., Addy, M. and Newcombe, R.: Comparison of the effect of toothpastes containing enzymes or antimicrobial compounds with a conventional fluoride toothpaste on the development of plaque and gingivitis. J. Clin. periodontol., 16: 295-299, 1989. Svatun, B., Saxton, C. A., Rolla, G. and van der Ouderaa, F.: One-year study of the efficacy of a dentifrice containing zinc citrate and triclosan to maintain gingival health. Scand. J. Dent., 97: 242 -246, 1989. 渡辺幸男, 藤橋弘, 日吉貴一郎, 三輪康, 楠公仁, 引間徹, 池田克已, 魚谷修, 佐相一夫, 武者良憲, 前山勉: 塩化ナトリウムおよび抗炎症剤含有歯磨剤の歯周疾患臨床効果. 日歯周誌, 24: 299-308, 1982. 森本清治: 唾液の酵素学的研究: 歯槽膿漏患者混合唾液の線溶能およびLysozyme活性について. 名市大医誌, 18: 875-881, 1967. Anthony, R.V., Margaret, E.P., William, D. and Robin, M. D.: A review of plaque, gingivitis, calculus and caries clinical efficacy studies with a dentifrice containing triclosan and PVM/MA copolymer. J. Clin. Dent., Sp. Issue 4: 31-41, 1993. Suzuki, T., Takahashi, H., Komiya, M., Horiuchi, K. and Nagasawa, S. : Vasopeptides. Adv., Exp. Med. Biol., 21 : 77-86, 1971. Rocha e silva, M. and Jeixeira, R.M. : Role played by leucocytes, plateletes and plasma trypsine in peptone shock in the dog. Proc. Soc. Exp. Biol. & Med., 61 : 376-382, 1946. van der Ouderaa, F. J. G.: Human clinical studies of anti-plaque and anti-gingivitis agents dosed from a dentifrices. Embery, G. and Rolla, G., ed, Clinical and biological aspects of dentifrices, Oxford University Press, New York, 1992, 181-204. Cummins, D. : Zinc citrate/triclosan : A new antiplaque system for the control plaque and the prevention of gingivitis : Short-term clinical and mode of action studies. J. Clin. Periodontol., 18: 455-461, 1991. Haper. D. S., Mueller, L. J., Fine. J. B., Gordon, J. and Laster, L.L. : Clinical efficacy of a dentifrice and oral rinse containing sanguinaria extract and zinc chloride during six months of use. J. Periodontol., 61: 352-358, 1990. Saxton, C. A., Lane, R.M. and van der Ouderaa, F.: The effects of a dentifrice containing zinc salt and a non-cationic anti-microbial agent on plaque and gingivitis. J. Clin. periodontol., 14: 144-148, 1987. Marsh, P.D. : Zinc citrate and triclosan in the prevention of plaque and gingivitis Microbial aspects. J. Clin. Periodontol., 18: 462-467, 1991. 荒井法行, 奥津誠一郎, 佐藤秀一, 東風巧, 高野研一, 村井正大, 山本瑞哉, 三宅幹雄, 金子憲司: ポリリン酸ナトリウム, トラネキサム酸, フッ化ナトリウム配合歯磨剤の歯石予防および歯肉炎予防効果に関する研究-日歯周誌, 33: 678-684, 1991. 上野正, 金田敏郎, 風間正守: 歯肉炎の局所線溶能について. 口病誌, 34: 193-196, 1967. 渡辺幸男, 宮田隆, 楠公仁, 引間徹, 池田克已, 山崎洋治, 佐々木修二, 佐相一夫: 塩化ナトリウムおよび抗炎症剤配合歯磨剤の歯周治療科領域における臨床効果に関する研究. 歯薬療法, 3: 164-173, 1984. 佐野浩史, 山本瑞哉, 寺井明子, 菅沼信夫, 金子憲司, 栗山純雄: 殺菌剤および抗炎症剤配合液状歯磨剤の歯肉溝内濃度と殺菌効果に関する研究. 日歯周誌, 投稿予定 Die, H.: The gingival index, the plaque index and retention index systems. J. Periodontol., 38: 610-616, 1967. Kopczyk, R. A., Abrams. H., Brown. A. T., Matheny. J. L. and Kaplan. A. L.: Clinical and microbiological effects of a sanguinaria-containing mouthrinse and dentifrice with and without fluoride during 6 month of use. J. Periodontol., 62: 617-622, 1991. Palomo, F., Wantland, L., Sanchez, A., De Vizion, W., Carter, W. and Baines, E.: The effect of a dentifrice containing triclosan and a co-polymer on plaque formation and gingivities: Fouteenweeks clinical study. Am. J. Dent., 2: 231-237, 1989. 中尾俊一, 安井利一, 田中園治, 小野沢祐彦, 田中入, 大高義文, 菅沼信夫, 徳光史彦, 山本瑞哉, 森田十誉子: トラネキサム酸およびグリチルリチン酸ジカリウム配合歯磨剤の歯周疾患予防効果に関する研究. 口腔衛生会誌, 41: 643-653, 1991. 池田克已, 引間徹, 楠公仁, 渡辺幸男, 藤橋弘, 日吉貴一郎, 菅沼信夫, 岩崎浩一郎: トラネキサム酸添加歯磨剤の臨床効果に関する研究. 日歯周誌, 23: 437-450, 1981. Christersson, L.J., Grossi, S.G., Dunford. R.G., Machtei, E. E. and Genco, R.J. : Dental plaque and calculus: Risk indicators for their formation. J. Dent. Res., 71: 1425-1430, 1992. 渡辺幸男, 佐藤巌雄, 下島孝裕, 宮田隆, 楠公仁, 引間徹, 池田克已, 山崎洋治, 福地直二, 菅沼信夫, 平山豊, 林達男, 亀山省司: オウバクエキス配合歯磨剤の歯周疾患予防効果に関する研究 (第1報) -オウバクエキスの抗炎症効果および 臨床効果について-. 日歯周誌, 30: 875-886, 1988. Saxton, C. A., Svatun, B. and Lloyd, A. M.: Antiplaque effects and mode of action of a combination of zinc citrate and a nonionic antimicrobial agent. Scand. J. Dent., 96: 212-217, 1988. 林琴生: 歯周疾患歯肉のPlasmin系物質, とくにその活性度の測定について. 日歯漏誌, 9: 27-33, 1967. 佐藤重孝: 唾液の酵素学的研究: 人唾液の線溶物質とLysozymeの分泌機能ならびに両酵素の生理学的動態名市大医誌, 20: 129-145, 1969. 河田則文, 長谷川格, 阪上吉秀, 溝口靖紘, 小林旬三, 近藤洋子, 森沢成司, 門奈丈之, 山本祐夫: グリチルリチンおよびグリチルレチン酸のアラキドン酸カスケードに及ぼす影響. 炎症, 9: 29-32, 1989. Silness, J. and Die, H.: Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta. Odont. Scand., 24: 747-759, 1964. Lucas, 0. N. : Increased fibrinolytic activity in the inflamed gingiva of beagle dogs. J. Dent. Res., 56: 1533-1538, 1977. |
| References_xml | – reference: 山内康平, 磯部敬, 藤田拓男: 動脈硬化と補体系-グリチルリチンの補体に及ぼす影響-臨床免疫, 13: 145-152, 1981. – reference: Jenkins, S., Addy, M. and Newcombe, R.: Studies on the effect of toothpaste rins on plaque regrowth (II). Triclosan with and without zinc citrate formulations. J. Clin. periodontol., 16: 385 -387, 1989 . – reference: Svatun, B., Saxton, C. A., Rolla, G. and van der Ouderaa, F.: One-year study of the efficacy of a dentifrice containing zinc citrate and triclosan to maintain gingival health. Scand. J. Dent., 97: 242 -246, 1989. – reference: Lucas, 0. N. : Increased fibrinolytic activity in the inflamed gingiva of beagle dogs. J. Dent. Res., 56: 1533-1538, 1977. – reference: 佐野浩史, 山本瑞哉, 寺井明子, 菅沼信夫, 金子憲司, 栗山純雄: 殺菌剤および抗炎症剤配合液状歯磨剤の歯肉溝内濃度と殺菌効果に関する研究. 日歯周誌, 投稿予定 – reference: Cummins, D. : Zinc citrate/triclosan : A new antiplaque system for the control plaque and the prevention of gingivitis : Short-term clinical and mode of action studies. J. Clin. Periodontol., 18: 455-461, 1991. – reference: Morn, J., Addy, M. and Newcombe, R.: Comparison of the effect of toothpastes containing enzymes or antimicrobial compounds with a conventional fluoride toothpaste on the development of plaque and gingivitis. J. Clin. periodontol., 16: 295-299, 1989. – reference: Palomo, F., Wantland, L., Sanchez, A., De Vizion, W., Carter, W. and Baines, E.: The effect of a dentifrice containing triclosan and a co-polymer on plaque formation and gingivities: Fouteenweeks clinical study. Am. J. Dent., 2: 231-237, 1989. – reference: Die, H.: The gingival index, the plaque index and retention index systems. J. Periodontol., 38: 610-616, 1967. – reference: Suzuki, T., Takahashi, H., Komiya, M., Horiuchi, K. and Nagasawa, S. : Vasopeptides. Adv., Exp. Med. Biol., 21 : 77-86, 1971. – reference: Rocha e Silva, M., Androde, S.O. and Jeixeira, R. M.: Fibrinolysis in peptone andanaphylactic shock in dog. Nature, 157: 801-802, 1946. – reference: van der Ouderaa, F. J. G.: Human clinical studies of anti-plaque and anti-gingivitis agents dosed from a dentifrices. Embery, G. and Rolla, G., ed, Clinical and biological aspects of dentifrices, Oxford University Press, New York, 1992, 181-204. – reference: Silness, J. and Die, H.: Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta. Odont. Scand., 24: 747-759, 1964. – reference: 佐藤重孝: 唾液の酵素学的研究: 健常者混合唾液の線溶能およびLysozyme活性ならびに齲蝕との関係. 名市大医誌, 18: 867-874, 1967. – reference: Kopczyk, R. A., Abrams. H., Brown. A. T., Matheny. J. L. and Kaplan. A. L.: Clinical and microbiological effects of a sanguinaria-containing mouthrinse and dentifrice with and without fluoride during 6 month of use. J. Periodontol., 62: 617-622, 1991. – reference: Anthony, R.V., Margaret, E.P., William, D. and Robin, M. D.: A review of plaque, gingivitis, calculus and caries clinical efficacy studies with a dentifrice containing triclosan and PVM/MA copolymer. J. Clin. Dent., Sp. Issue 4: 31-41, 1993. – reference: Gilbert, R.J. and Williams, P.E.O. : The oral retention and antiplaque efficacy of triclosan in human volunteers. Britt. J. Clin. Pharmacol., 23: 579-583, 1987. – reference: 林琴生: 歯周疾患歯肉のPlasmin系物質, とくにその活性度の測定について. 日歯漏誌, 9: 27-33, 1967. – reference: 池田克已, 引間徹, 楠公仁, 渡辺幸男, 藤橋弘, 日吉貴一郎, 菅沼信夫, 岩崎浩一郎: トラネキサム酸添加歯磨剤の臨床効果に関する研究. 日歯周誌, 23: 437-450, 1981. – reference: 上野正, 金田敏郎, 風間正守: 歯肉炎の局所線溶能について. 口病誌, 34: 193-196, 1967. – reference: Saxton, C. A., Svatun, B. and Lloyd, A. M.: Antiplaque effects and mode of action of a combination of zinc citrate and a nonionic antimicrobial agent. Scand. J. Dent., 96: 212-217, 1988. – reference: Marsh, P.D. : Zinc citrate and triclosan in the prevention of plaque and gingivitis Microbial aspects. J. Clin. Periodontol., 18: 462-467, 1991. – reference: 佐藤巌雄, 渡辺幸男, 下島孝裕, 小野寺修, 大沢一茂, 中島啓次, 栗橋豊, 真島徹楠公仁, 池田克已, 福地直二, 松本たまみ, 菅沼信夫, 平山豊, 亀山省司: オウバクエキス配合歯磨剤の歯周疾患予防効果に関する研究 (第2報) -オウバクエキス及び抗炎症剤配合歯磨剤の臨床効果について-. 日歯周誌, 30: 887-900, 1988. – reference: 佐藤重孝: 唾液の酵素学的研究: 人唾液の線溶物質とLysozymeの分泌機能ならびに両酵素の生理学的動態名市大医誌, 20: 129-145, 1969. – reference: 荒井法行, 奥津誠一郎, 佐藤秀一, 東風巧, 高野研一, 村井正大, 山本瑞哉, 三宅幹雄, 金子憲司: ポリリン酸ナトリウム, トラネキサム酸, フッ化ナトリウム配合歯磨剤の歯石予防および歯肉炎予防効果に関する研究-日歯周誌, 33: 678-684, 1991. – reference: 森本清治: 唾液の酵素学的研究: 歯槽膿漏患者混合唾液の線溶能およびLysozyme活性について. 名市大医誌, 18: 875-881, 1967. – reference: Rocha e silva, M. and Jeixeira, R.M. : Role played by leucocytes, plateletes and plasma trypsine in peptone shock in the dog. Proc. Soc. Exp. Biol. & Med., 61 : 376-382, 1946. – reference: Saxton, C. A.: The effects of a dentifrice containing zinc citrate and 2, 4, 4'-trichloro-2'-hydroxydiphenyl ether. J. 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| SubjectTerms | Dipotassium glycyrrhizinate Liquid dentifrice Prevention of Periodontal Disease Tranexamic acid Triclosan |
| Title | The Effects of a Liquid Dentifrice Containing an Antibacterial Agent and Anti-inflammatory Agents on The Prevention of Periodontal Disease |
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