The Effects of a Liquid Dentifrice Containing an Antibacterial Agent and Anti-inflammatory Agents on The Prevention of Periodontal Disease

• Published in: Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) Vol. 36; no. 1; pp. 215 - 222
• Main Authors: FUJITA, Kouji, OHISHI, Mika, ANAI, Kyoichi, WATANABE, Yukio, NAKAGIMA, Keiji, IKEDA, Katsumi, OHTSUKA, Hideharu, SHIMOJIMA, Takahiro, SUDOU, Youtarou, KURIHARA, Noriyoshi, TATSUMI, Junichi, OBARA, Toshihiko, ICHIMURA, Koh
• Format: Journal Article
• Language: Japanese
• Published: JAPANESE SOCIETY OF PERIODONTOLOGY 1994
• Subjects: Dipotassium glycyrrhizinate; Liquid dentifrice; Prevention of Periodontal Disease; Tranexamic acid; Triclosan
• ISSN: 0385-0110; 1880-408X
• DOI: 10.2329/perio.36.215

The purpose of this clinical study was to evaluate the effects of a test liquid dentifrice containing 0.1% triclosan, 0.05% tranexamic acid and 0.05% dipotassium glycyrrhizinate on the control of dental plaque, and the prevention and/or improvement of periodontal disease in comparison with a placebo dentifrice. Subjects were 60 adults who had no serious oral and systemic disease. They were divided into two groups of equal size and performed toothbrushing twice a day for fuor weeks. The results were summarized as follows: 1) The test liquid dentifrice was significantry superior to the placebo dentifrice in improving the gingival index (P<0.01) and the plaque index P<0.01). (2) No particular side effects were observed during this clinical study.