Alcohol-induced tight junction dysfunction primes airways for RSV infection

Not only does alcohol increase tight junction permeability, but it also perturbs wound healing. Since RSV infection (alone) is known to cause shedding of airway epithelium resulting in an injury wound, we suspect that alcohol exacerbates airway epithelial RSV-induced wounds and increases the time it...

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Bibliographic Details
Published inAlcohol (Fayetteville, N.Y.) Vol. 47; no. 7; p. 575
Main Authors Simet, S.M, Wyatt, T.A, Pavlik, J.A, Sisson, J.H
Format Journal Article
LanguageEnglish
Published Philadelphia Elsevier Inc 01.11.2013
Elsevier Limited
Subjects
Alcohol
Bacterial infections
Infections
Kinases
Permeability
Psychiatry
Wound healing
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Summary:Not only does alcohol increase tight junction permeability, but it also perturbs wound healing. Since RSV infection (alone) is known to cause shedding of airway epithelium resulting in an injury wound, we suspect that alcohol exacerbates airway epithelial RSV-induced wounds and increases the time it takes for migrating airway epithelia cells to heal the wound.
ISSN:0741-8329
1873-6823
DOI:10.1016/j.alcohol.2013.09.033