IMPACT OF MORPHINE ON PHARMACOKINETIC AND PHARMACODYNAMIC PROFILES OF TICAGRELOR IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION UNDERGOING PRIMARY PERCUTANEOUS CORONARY INTERVENTION

The PK profile tracked PD findings, showing a delay in peak plasma concentrations of both ticagrelor and AR-C124910XX in patients receiving morphine, although overall drug exposure was similar between groups (Figure).

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Bibliographic Details
Published inJournal of the American College of Cardiology Vol. 65; no. 10; p. A1751
Main Authors Franchi, Francesco, Rollini, Fabiana, Cho, Jung Rae, Bhatti, Mona, DeGroat, Christopher, Ferrante, Elisabetta, Dunn, Elizabeth C, Nanavati, Amit, Carraway, Edward, Suryadevara, Siva, Zenni, Martin M, Guzman, Luis A, Bass, Theodore A, Angiolillo, Dominick J
Format Journal Article
LanguageEnglish
Published New York Elsevier Inc 17.03.2015
Elsevier Limited
Subjects
Cardiology
Cardiovascular
Heart attacks
Internal Medicine
Medical research
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Summary:The PK profile tracked PD findings, showing a delay in peak plasma concentrations of both ticagrelor and AR-C124910XX in patients receiving morphine, although overall drug exposure was similar between groups (Figure).
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(15)61751-X