High-Mobility Group Box-1 (HMGB1) participates in the pathogenesis of alcoholic liver disease (ALD)

Hepatocytes appeared to be a major source of these HMGB1 isoforms. [...]hepatocyte HMGB1 participates in the pathogenesis of ALD and undergoes posttranslational modifications (PTMs) that could condition its toxic effects.

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Bibliographic Details
Published inAlcohol (Fayetteville, N.Y.) Vol. 48; no. 7; p. 729
Main Author Ge, X
Format Journal Article
LanguageEnglish
Published Philadelphia Elsevier Inc 01.11.2014
Elsevier Limited
Subjects
Kinases
Liver cirrhosis
Liver diseases
Pathogenesis
Psychiatry
Rodents
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Summary:Hepatocytes appeared to be a major source of these HMGB1 isoforms. [...]hepatocyte HMGB1 participates in the pathogenesis of ALD and undergoes posttranslational modifications (PTMs) that could condition its toxic effects.
ISSN:0741-8329
1873-6823
DOI:10.1016/j.alcohol.2014.09.011