Stress proteins: nomenclature, division and functions
The heat shock response, characterized by increased expression of heat shock proteins (Hsps) is induced by exposure of cells and tissues to extreme conditions that cause acute or chronic stress. Hsps function as molecular chaperones in regulating cellular homeostasis and promoting survival. If the s...
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Published in | Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia Vol. 145; no. 2; pp. 39 - 47 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Czech Republic
01.12.2001
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Subjects | |
Online Access | Get full text |
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Summary: | The heat shock response, characterized by increased expression of heat shock proteins (Hsps) is induced by exposure of cells and tissues to extreme conditions that cause acute or chronic stress. Hsps function as molecular chaperones in regulating cellular homeostasis and promoting survival. If the stress is too severe, a signal that leads to programmed cell death, apoptosis, is activated, thereby providing a finely tuned balance between survival and death. In addition to extracellular stimuli, several nonstressfull conditions induce Hsps during normal cellular growth and development. The enhanced heat shock gene expression in response to various stimuli is regulated by heat shock transcription factors. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 1213-8118 1804-7521 |
DOI: | 10.5507/bp.2001.010 |