Stress proteins: nomenclature, division and functions

The heat shock response, characterized by increased expression of heat shock proteins (Hsps) is induced by exposure of cells and tissues to extreme conditions that cause acute or chronic stress. Hsps function as molecular chaperones in regulating cellular homeostasis and promoting survival. If the s...

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Published inBiomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia Vol. 145; no. 2; pp. 39 - 47
Main Authors Kopecek, P, Altmannová, K, Weigl, E
Format Journal Article
LanguageEnglish
Published Czech Republic 01.12.2001
Subjects
Animals
Heat-Shock Proteins - classification
Heat-Shock Proteins - genetics
Heat-Shock Proteins - physiology
Heat-Shock Response - physiology
Humans
Terminology as Topic
Transcription, Genetic
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Summary:The heat shock response, characterized by increased expression of heat shock proteins (Hsps) is induced by exposure of cells and tissues to extreme conditions that cause acute or chronic stress. Hsps function as molecular chaperones in regulating cellular homeostasis and promoting survival. If the stress is too severe, a signal that leads to programmed cell death, apoptosis, is activated, thereby providing a finely tuned balance between survival and death. In addition to extracellular stimuli, several nonstressfull conditions induce Hsps during normal cellular growth and development. The enhanced heat shock gene expression in response to various stimuli is regulated by heat shock transcription factors.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ISSN:1213-8118
1804-7521
DOI:10.5507/bp.2001.010