An extracellular residue determines the agonist specificity of V 2 vasopressin receptors

The specific V 2 agonist 1-deamino [8- d-arginine]-vasopressin (dDAVP), used for treatment of central diabetes insipidus, binds to vasopressin V 2 receptors from human, bovine and rat kidney with an affinity that is similar to that of the natural hormone vasopressin. In contrast, the V 1 receptors a...

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Bibliographic Details
Published inFEBS letters Vol. 362; no. 1; pp. 19 - 23
Main Authors Ufer, Elke, Postina, Rolf, Gorbulev, Valentin, Fahrenholz, Falk
Format Journal Article
LanguageEnglish
Published Elsevier B.V 27.03.1995
Subjects
Central diabetes insipidus
Receptor subtype
Specificity
Vasopressin
Central diabetes insipidus
Specificity
OT
Receptor subtype
LVP
DAVP
CDI
dDAVP
AVP
Vasopressin
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Summary:The specific V 2 agonist 1-deamino [8- d-arginine]-vasopressin (dDAVP), used for treatment of central diabetes insipidus, binds to vasopressin V 2 receptors from human, bovine and rat kidney with an affinity that is similar to that of the natural hormone vasopressin. In contrast, the V 1 receptors and the porcine V 2 receptor do not tolerate a D-arginine in position 8 of vasopressin. By site directed mutagenesis of the cloned bovine and porcine V 2 receptors we identified a residue (Asp-103) in the first extracellular loop of vasopressin receptors which is responsible for high affinity binding of dDAVP.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(95)00150-8