In vivo behavior of carboxymethylcellulose based microgels containing 67Cu

[Display omitted] Using a mouse model, an organ distribution for microgels of carboxymethyl cellulose cross-linked with 67Cu2+ ions was investigated and compared with the distribution of free 67Cu2+ ions from 67CuCl2. The clearance of the microgels through both liver and kidneys was demonstrated. An...

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Published inMendeleev communications Vol. 32; no. 5; pp. 658 - 660
Main Authors Orlova, Marina A., Spiridonov, Vasiliy V., Badun, Gennadii A., Trofimova, Tatiana P., Orlov, Alexey P., Zolotova, Alena S., Priselkova, Anna B., Aleshin, Gleb Yu, Chernysheva, Maria G., Yaroslavov, Alexander A., Kalmykov, Stepan N.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.09.2022
Subjects
67Cu
carboxymethyl cellulose
microgel
mouse model
organ distribution
radiation stability
tritium
tritium
microgel
mouse model
carboxymethyl cellulose
67Cu
organ distribution
radiation stability
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Summary:[Display omitted] Using a mouse model, an organ distribution for microgels of carboxymethyl cellulose cross-linked with 67Cu2+ ions was investigated and compared with the distribution of free 67Cu2+ ions from 67CuCl2. The clearance of the microgels through both liver and kidneys was demonstrated. An additional examination of distribution for [3H]CMC microparticles and [3H]CMC–Cu microgels revealed no copper release from the microgels in vivo.
ISSN:0959-9436
DOI:10.1016/j.mencom.2022.09.030