Synthesis of spiro[pyrrolidine-2,2 '-adamantane] nitrones and nitroxides

Starting from 2-nitroadamantane, spiro[pyrrolidine-2,2'-adamantane] nitrones and nitroxides were synthesised as new lipophilic spin traps and spin labels. The reduction of nitrones and nitroxides offers a new route to aminoadamantane derivatives.

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Bibliographic Details
Published inSynthesis (Stuttgart) no. 2; pp. 255 - 259
Main Authors Sar, CP, Osz, E, Jeko, J, Hideg, K
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.02.2005
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
adamantane
free radicals
Grignard reaction
INHIBITION
heterocycles
CROSS-LINKING
RADICALS
AMINOADAMANTANE DERIVATIVES
SPIN-LABEL
nitrone
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Summary:Starting from 2-nitroadamantane, spiro[pyrrolidine-2,2'-adamantane] nitrones and nitroxides were synthesised as new lipophilic spin traps and spin labels. The reduction of nitrones and nitroxides offers a new route to aminoadamantane derivatives.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2004-834937