Novel chiral multidentate P3N4-type ligand for asymmetric transfer hydrogenation of aromatic ketones

Novel chiral multidentate P3N4-type ligand has been synthesized and characterized by NMR and HRMS.Using i-PrOH as solvent and hydrogen source, asymmetric transfer hydrogenation of various ketones was investigated. The catalyst generated in situ from chiral multidentate aminophosphine ligand（R,R,R,R）...

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Bibliographic Details
Published inChinese chemical letters Vol. 28; no. 1; pp. 97 - 100
Main Authors Tao, Meng, Wu, Fang, Li, Teng, Li, Yan-Yun, Gao, Jing-Xing
Format Journal Article
LanguageEnglish
Published NEW YORK Elsevier B.V 2017
Elsevier
Subjects
Aromatic ketones
Asymmetric catalysis
Asymmetric transfer hydrogenation
Chemistry
Chemistry, Multidisciplinary
Chiral alcohols
Chiral aminophosphine ligand
Physical Sciences
Science & Technology
Aromatic ketones
Asymmetric catalysis
Chiral alcohols
Chiral aminophosphine ligand
Asymmetric transfer hydrogenation
CATALYSIS
P,N-LIGANDS
REDUCTION
COMPLEXES
IRON
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Summary:Novel chiral multidentate P3N4-type ligand has been synthesized and characterized by NMR and HRMS.Using i-PrOH as solvent and hydrogen source, asymmetric transfer hydrogenation of various ketones was investigated. The catalyst generated in situ from chiral multidentate aminophosphine ligand（R,R,R,R）-3 and IrCl（CO）（PPh3）2exhibited highly catalytic activity and excellent enantioselectivity under mild conditions, achieving the corresponding chiral alcohols with up to 99% yield and 99% ee.
Bibliography:11-2710/O6
Chiral aminophosphine ligand;Asymmetric catalysis;Asymmetric transfer hydrogenation;Chiral alcohols;Aromatic ketones
Novel chiral multidentate P3N4-type ligand has been synthesized and characterized by NMR and HRMS.Using i-PrOH as solvent and hydrogen source, asymmetric transfer hydrogenation of various ketones was investigated. The catalyst generated in situ from chiral multidentate aminophosphine ligand（R,R,R,R）-3 and IrCl（CO）（PPh3）2exhibited highly catalytic activity and excellent enantioselectivity under mild conditions, achieving the corresponding chiral alcohols with up to 99% yield and 99% ee.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2016.05.028