A near-infrared squaraine dye for Cu2+-specific detection and fluorescence imaging in living cells and mice

Herein, a highly selective and sensitive squaraine dye (F-0) for Cu2+ detection was developed. Upon addition of Cu2+, F-0 could greatly decrease absorption peak accompanying with fluorescent quenching about 170 folds. The detection limit can reach as low as 7.2 nmol/L. F-0 showed excellent water sol...

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Bibliographic Details
Published inDyes and pigments Vol. 206; p. 110600
Main Authors Yu, Lijia, Fan, Xinli, Zhao, Han, Ding, Chunguang, Zhang, Yinglin, Fan, Jingguang, Tang, Xinjing
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.10.2022
Subjects
Copper ion
living cells
Mice
Near-infrared probe
Squaraine dye
PBS
living cells
Copper ion
FI
DMSO
Mice
Squaraine dye
Near-infrared probe
DMF
ACN
Tris
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Summary:Herein, a highly selective and sensitive squaraine dye (F-0) for Cu2+ detection was developed. Upon addition of Cu2+, F-0 could greatly decrease absorption peak accompanying with fluorescent quenching about 170 folds. The detection limit can reach as low as 7.2 nmol/L. F-0 showed excellent water solubility and achieved naked eye detection of Cu2+. A paper strip pre-stained with F-0 solution was fabricated and showed color changed from blue to colorless upon addition of Cu2+. F-0 exhibited highly specific to Cu2+ over other metal ions. Furthermore, on the basic of low cell cytotoxicity, F-0 could be utilized to monitor Cu2+ in living cell and mice via fluorescence imaging. These results showed that F-0 has great potential for a more complex applications. [Display omitted]
ISSN:0143-7208
1873-3743
DOI:10.1016/j.dyepig.2022.110600