Anti-dopamine antibodies: effects on behavior in an "open field," pain sensitivity, CNS monoamine content, and functional activity of immunocytes in C57Bl/6 mice

• Published in: Neuroscience and behavioral physiology Vol. 31; no. 1; pp. 7 - 13
• Main Authors: Trekova, N A, Vetrilé, L A, Basharova, L A, Mikovskaya, O I, Khlopushina, T G
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01.01.2001
• Subjects: Animals; Antibodies; Antibodies, Blocking - pharmacology; B-Lymphocytes - drug effects; B-Lymphocytes - immunology; Behavior; Behavior, Animal - drug effects; Behavior, Animal - physiology; Biogenic Monoamines - metabolism; Central Nervous System - metabolism; Central Nervous System - physiology; Dopamine; Dopamine - immunology; Immune system; Lymphocytes; Macrophages, Peritoneal - drug effects; Macrophages, Peritoneal - immunology; Male; Metabolites; Mice; Mice, Inbred C57BL; Motor Activity - drug effects; Motor Activity - physiology; Pain; Pain - psychology; Pain Measurement - drug effects; Phagocytosis - drug effects; Physiology; Proteins; Serotonin; T-Lymphocytes - drug effects; T-Lymphocytes - immunology
• ISSN: 0097-0549; 1573-899X
• DOI: 10.1023/A:1026661811317

Single i.p. doses of anti-dopamine antibodies were given to C57Bl/6 mice. This resulted in inhibition of motor activity in a large proportion of the animals in the "open field" test, which lasted five days. Hyperalgesia, detected 1.5 h and 1 day after doses of antibody, was replaced by analgesia on day 5. There was a sharp reduction in the levels of dopamine and its metabolites in the cerebral cortex at 1 and 5 days; the serotonin level was increased 1 day after doses of antibody, and was significantly decreased at 5 days. There was no effect on cells of the immune system. The possible mechanisms of the neurotropic action of these antibodies are discussed.