Study of the Maturation of the Child’s Brain Using 31P-MRS

• Published in: Pediatric neurology Vol. 18; no. 4; pp. 305 - 310
• Main Authors: Hanaoka, Shigeru, Takashima, Sachio, Morooka, Keiichi
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.04.1998; Elsevier
• Subjects: Adenosine Triphosphate - analysis; Adolescent; Biological and medical sciences; Cerebellum - growth & development; Cerebellum - metabolism; Cerebral Cortex - growth & development; Cerebral Cortex - metabolism; Child; Energy Metabolism; Female; Fourier Analysis; Humans; Infant; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging; Male; Medical sciences; Nervous system; Phosphocreatine - analysis; Phosphorus Isotopes; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Reference Values; Human; Cerebellum; Central nervous system; Development; Exploration; Phosphorus; NMR spectrometry; Child; Brain (vertebrata)
• ISSN: 0887-8994; 1873-5150
• DOI: 10.1016/S0887-8994(97)00201-4

The maturation of human cerebrum and cerebellum in 37 normal children aged 4 months to 13 years 8 months was evaluated by 31P-magnetic resonance spectroscopy using two different conditions of repetition time (TR) (TR = 3 seconds and 15 seconds) in each region. The results were as follows. First, the PME/PDE, PCr/γ-ATP and Pi/PCr ratios differed between the cerebrum and the cerebellum. The PME/PDE and PCr/γ-ATP ratios were greater in the cerebellum than in the cerebrum. However, the Pi/PCr ratio was smaller in the cerebellum than in the cerebrum. At TR = 3 seconds, the ratio of (PME/PDE ratio in the cerebellum)/(PME/PDE ratio in the cerebrum) and the ratio of (PCr/γ-ATP ratio in the cerebellum)/(PCr/γ-ATP ratio in the cerebrum) manifested a nearly constant value independent of age. Second, the phosphomonoester peak in the cerebrum contained a substance with a longer relaxation time than 3 seconds; this substance was present in large amounts in the early period, then gradually decreased during maturation.