Single-nucleotide polymorphism rs11562975 of the thermosensitive ion channel TRPM8 gene and human sensitivity to cold and menthol

• Published in: Human physiology Vol. 37; no. 2; pp. 188 - 192
• Main Authors: Kozyreva, T. V., Tkachenko, E. Ya, Potapova, T. A., Romashchenko, A. G., Voevoda, M. I.
• Format: Journal Article
• Language: English
• Published: Dordrecht SP MAIK Nauka/Interperiodica 01.03.2011
• Subjects: Biomedical and Life Sciences; Biomedicine; Human Physiology; Life Sciences; menthol; 8 gene polymorphism; temperature sensitivity
• ISSN: 0362-1197; 1608-3164
• DOI: 10.1134/S0362119711020101

The examination of subjects from the Russian ethnic group revealed that 20.3% of them had the heterozygous genotype containing the C -allele in the rs 11562975 ( G → C ) single-nucleotide polymorphism located in exon 7 of the gene encoding the temperature-sensitive ion channel TRPM 8. Functional differences associated with the sensitivity to cold and menthol were revealed in subjects with different rs 11562975 polymorphism genotypes ( GG and GC ). The subjects with the heterozygous genotype GC were characterized by increased sensitivity to cold and decreased sensitivity to menthol, an agonist of the ion channel TRPM 8, compared to the subjects with the homozygous genotype GG