Neurocognitive function in patients with negative thought disorders

• Published in: European psychiatry Vol. 64; no. S1; p. S794
• Main Authors: Fateev, I., Omelchenko, M., Pluzhnikov, I.
• Format: Journal Article
• Language: English
• Published: Paris Cambridge University Press 01.04.2021
• Subjects: Abstract; E-Poster Viewing; Executive function; Executive functions; Negative thought disorders; Neurocognitive function; Schizophrenic spectrum disorder
• ISSN: 0924-9338; 1778-3585
• DOI: 10.1192/j.eurpsy.2021.2100

Introduction Negative thought disorders are found in various diagnoses in clinical practice. These symptoms may show a possible psychosis continuum and may be taken into account when assessing schizophrenic risk. Neurocognitive functioning of patients with negative thought disorders need to be clarified. Objectives Aim of the study is to identify and validate the differences of executive functions between patients with negative thought disorders and patients without thought disorders. Methods Used a standardized neuropsychological test battery. There were 15 patients with negative thought disorders (affective disorders, personality disorders, schizophrenic spectrum disorders) and 18 patients with depressive episode without thought disorders in the research. Patients aged 17-25 years. The Mann–Whitney U test and ANOVA were used for statistical analysis. Results Significant results were obtained from The Verbal Fluency Test, The Design Fluency Test, The Digit span, The Rey-Osterrieth Complex Figure and Bidstrup’s drawings (All tests have p-values less than 0.05). In the methods listed above, the results in the group of patients with negative thought disorders are significantly lower than in the group of patients without thought disorders. Conclusions The data indicate a violation of Executive functions among patients with negative thought disorders: inhibitory control, planning and regulation, working memory, difficulty switching, which related to left frontal lobe dysfunction. A lack of simultaneity and understanding figurative language, which is associated with right hemisphere dysfunction. Disclosure The reported study was funded by RFBR, project number 20-013-00772