99mTc-2GAM: A tracer for renal imaging

• Published in: Nuclear medicine and biology Vol. 23; no. 8; pp. 927 - 933
• Main Authors: Gianolli, Luigi, Dosio, Flaviano, Matarrese, Mario, Colombo, Fabio, Cutler, Cathy, Stepniak-Biniakiewicz, Danuta, Deutsch, Edward, Savi, Annarita, Lucignani, Giovanni, Fazio, Ferruccio
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.11.1996; Elsevier
• Subjects: Adult; Animals; Biological and medical sciences; DMSA; Female; Glycine - analogs & derivatives; Glycine - chemical synthesis; Glycine - pharmacokinetics; Humans; Isotope Labeling; Kidney - diagnostic imaging; Kidney - metabolism; Male; Medical sciences; Mice; Organotechnetium Compounds - chemical synthesis; Organotechnetium Compounds - pharmacokinetics; Radionuclide Imaging; Radiopharmaceuticals - chemical synthesis; Radiopharmaceuticals - pharmacokinetics; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Rats; Renal imaging; Renal mass; Succimer - pharmacokinetics; Technetium Tc 99m Dimercaptosuccinic Acid; Technology. Biomaterials. Equipments. Material. Instrumentation; Tissue Distribution; DMSA; Renal mass; Renal imaging; Dose repartition; Performance evaluation; Human; Radiolabelling; Toxicity; Technetium; Experimental study; Kidney; Bidentate ligand; Urinary system; Animal; Medical imagery; Chemical synthesis
• ISSN: 0969-8051; 1872-9614
• DOI: 10.1016/S0969-8051(96)00135-7

We propose a renal imaging agent, the 99mTc complex of the bidentate- N,S chelate N-(mercaptoacetyl) glycine ( 99mTc-2GAM), with the imaging characteristics of 99mTc-DMSA but a faster kidney uptake; chemical evidence supports the formulation of 99mTc-2GAM as [Tc V(O)(GAM) 2] −. After biodistribution and toxicity studies in animals, 99mTc-2GAM was evaluated in five normal volunteers. 99mTc-2GAM is rapidly cleared from the blood ( t 1 2 = 9 min ) and 50% of the ID is excreted in the urine in the first 2 h. Dynamic data show a rapid renal uptake that increases up to 1 h with no significant wash-out between 1 and 8 h. The uptake in each kidney ranges from 11.3% to 20.7% ID. Low, stable liver uptake is observed. No significant activity is detected in other organs. We showed no differences between 99mTc-2GAM and 99mTc-DMSA compared in three patients with unilateral kidney disease. We conclude that 99mTc-2GAM has good practical and dosimetric features for renal imaging.