Triphosgene: A versatile reagent for Bischler-Napieralski reaction

Triphosgene causes direct formation of quaternary benzo[c]phenanthridines such as anti-tumor active nitidine (2a) chloride by Bischler-Napieralski reaction of 2-phenyl-1-(N-methylformamido)naphthalenes under heating in acetonitrile.

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Bibliographic Details
Published inHeterocycles Vol. 54; no. 1; pp. 437 - 438
Main Authors Saito, T, Yoshida, M, Ishikawa, T
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 01.01.2001
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
RUTACEOUS PLANTS
dehydration
benzo[c]phenanthridinium chloride
2-phenyl-1(N-methylformamido)naphthalene
BENZOPHENANTHRIDINE ALKALOIDS
CHEMICAL-CONSTITUENTS
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Summary:Triphosgene causes direct formation of quaternary benzo[c]phenanthridines such as anti-tumor active nitidine (2a) chloride by Bischler-Napieralski reaction of 2-phenyl-1-(N-methylformamido)naphthalenes under heating in acetonitrile.
ISSN:0385-5414
DOI:10.3987/com-00-s(i)44