Oleic acid reduces oxidative stress in rat brain induced by some anticancer drugs

• Published in: Chemico-biological interactions Vol. 398; p. 111086
• Main Authors: Calderón Guzmán, David, Juárez Olguín, Hugo, Osnaya Brizuela, Norma, Ortíz Herrera, Maribel, Trujillo Jimenez, Francisca, Valenzuela Peraza, Armando, Labra Ruiz, Norma, Santamaria Del Angel, Daniel, Barragán Mejía, Gerardo
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.08.2024
• Subjects: Anticancer; Brain; Nitropropionic acid; oxidative damage; Brain; oxidative damage; Anticancer; Nitropropionic acid
• ISSN: 0009-2797; 1872-7786; 1872-7786
• DOI: 10.1016/j.cbi.2024.111086

Oleic acid (OA) is a monounsaturated compound with many health-benefitting properties such as obesity prevention, increased insulin sensitivity, antihypertensive and immune-boosting properties, etc. The aim of this study was to analyze the effect of oleic acid (OA) and some anticancer drugs against oxidative damage induced by nitropropionic acid (NPA) in rat brain. Six groups of Wistar rats were treated as follows: Group 1, (control); group 2, OA; group 3, NPA + OA; group 4, cyclophosphamide (CPP) + OA; group 5, daunorubicin (DRB) + OA; and group 6, dexrazoxane (DXZ) + OA. All compounds were administered intraperitoneally route, every 24 h for 5 days. Their brains were extracted to measure lipoperoxidation (TBARS), H2O2, Ca+2, Mg+2 ATPase activity, glutathione (GSH) and dopamine. Glucose, hemoglobin and triglycerides were measured in blood. In cortex GSH increased in all groups, except in group 2, the group 4 showed the highest increase of this biomarker. TBARS decrease, and dopamine increase in all regions of groups 4, 5 and 6. H2O2 increased only in cerebellum/medulla oblongata of group 5 and 6. ATPase expression decreased in striatum of group 4. Glucose increased in group 6, and hemoglobin increased in groups 4 and 5. These results suggest that the increase of dopamine and the antioxidant effect of oleic acid administration during treatment with oncologic agents could result in less brain injury. •Oleic acid reduces brain injury produced by anticancer drugs in rats.•Cardioxane increases dopamine levels in cortex, striatum and medula oblongata.•Cyclophosphamide increases dopamine levels in cortex, striatum and medula oblongata.•Daunorrubicine increases dopamine levels in cortex, striatum and medula oblongata.•Neuroprotection of oleic acid is by its antioxidant effect.