SYNTHESIS OF QUINOLINE DERIVATIVES BY AN IMPROVED DOEBNER-VON MILLER REACTION USING A RECYCLABLE Ag(I)-EXCHANGED MONTMORILLONITE K10 CATALYST

The Doebner-von Miller synthesis of quinolines under solvent-free conditions is described, catalyzed by recyclable Ag(I)-exchanged Montmorillonite K10. The desired products are obtained in good to excellent yields and the reaction accommodates both aromatic and aliphatic alpha,beta-unsaturated aldeh...

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Bibliographic Details
Published inHeterocycles Vol. 92; no. 12; pp. 2213 - 2224
Main Authors Jayram, Janeeka, Jeena, Vineet
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 2016
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
REUSABLE CATALYST
ACID
MECHANISM
ONE-POT SYNTHESIS
ALKYLATION
QUINALDINES
MICROWAVE IRRADIATION
SKRAUP
CLAY
CYCLIZATION
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Summary:The Doebner-von Miller synthesis of quinolines under solvent-free conditions is described, catalyzed by recyclable Ag(I)-exchanged Montmorillonite K10. The desired products are obtained in good to excellent yields and the reaction accommodates both aromatic and aliphatic alpha,beta-unsaturated aldehydes making this process an attractive method for the synthesis of substituted quinolines. In addition, the Ag(I)-exchanged Montmorillonite K10 catalyst can be recovered and reused up to 5 times with excellent activity.
ISSN:0385-5414
1881-0942
DOI:10.3987/COM-16-13564