Long non-coding RNA HOTAIR: A biomarker and therapeutic target in urological tumors

• Published in: Pathology, research and practice Vol. 262; p. 155549
• Main Authors: Abida, Eltaib, Lina, Alhazmi, Bshayer Hmdan, Alzahrani, Abdullah R., Asdaq, Syed Mohammed Basheeruddin, Ali, Abuzer, Aldhafiri, Futoon Jamal, Alruwaili, Wafaa T., Al-Hajeili, Marwan, Abdulkhaliq, Altaf A., Rabaan, Ali A., Imran, Mohd
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.10.2024
• Subjects: Biomarkers, Tumor - genetics; Bladder; Gene Expression Regulation, Neoplastic - genetics; HOTAIR; Humans; Kidney; Long non coding RNA; RNA, Long Noncoding - genetics; Urologic cancer; Urologic Neoplasms - genetics; Urologic Neoplasms - pathology; HOTAIR; Bladder; Long non coding RNA; Urologic cancer; Kidney
• ISSN: 0344-0338; 1618-0631; 1618-0631
• DOI: 10.1016/j.prp.2024.155549

Long non-coding RNAs (lncRNAs) significantly influence gene regulation across epigenetic, transcriptional, and post-transcriptional levels through their interactions with DNA, RNA, and proteins. There is growing evidence of lncRNAs' critical roles in the emergence and progression of various diseases, including urological tumors (UTs), such as cancers of the kidney, bladder, and prostate. Research increasingly links lncRNA dysregulation to diverse cellular processes like invasion, metastasis, apoptosis, and chromatin remodeling. Among these, HOTAIR stands out for its pivotal role in oncogenesis, impacting treatment resistance, cell migration, proliferation, survival, and genomic integrity. This review provides an overview of HOTAIR's functions, its identification, and its biological significance. Furthermore, it delves into HOTAIR's involvement in UTs, underlining its potential as a therapeutic target and biomarker for innovative approaches to treating these cancers.