Stereospermum tetragonam as an antidiabetic agent by activating PPARγ and GLUT4

Present study evaluates the anti-diabetic activity of S. tetragonam LC-MS/MS experiments showed the presence of two novel molecules C1 and C2, which were further taken for in silico study against PPARγ. Cell culture studies with A431 cells in the presence of crude aqueous extract showed the elevated...

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Bibliographic Details
Published inBangladesh Journal of Pharmacology Vol. 9; no. 2
Main Authors Kingsley, Bino, KP, Arun, Selvaraj, Stalin, Pemiah, Brindha
Format Journal Article
LanguageEnglish
Published Bangladesh Pharmacological Society 26.06.2014
Subjects
Diabetes
GLUT-4
in silico
PPARγ
Stereospermum tetragonam
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Summary:Present study evaluates the anti-diabetic activity of S. tetragonam LC-MS/MS experiments showed the presence of two novel molecules C1 and C2, which were further taken for in silico study against PPARγ. Cell culture studies with A431 cells in the presence of crude aqueous extract showed the elevated level of PPARγ and GLUT4 and also confirmed using in silico studies. Thus, the present study proves the mecode of action of S. tetragonam as an antidiabetic drug.
ISSN:1991-007X
1991-0088
DOI:10.3329/bjp.v9i2.18488