Anticancer Efficiency of Curcumin on Ovarian Cancer

Objectives: Ovarian cancer is one of the most common malignancies in women, and it is quite difficult to cure. In order to treat the disease, chemotherapy is often performed as adjuvant therapy following the surgery or neo-adjuvant cure for the pre-operative purpose. While the strategy is an effecti...

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Bibliographic Details
Published inJournal of Basic and Clinical Health Sciences Vol. 3; no. 2; p. 78
Main Author Kocal, Gizem Calibasi
Format Journal Article
LanguageEnglish
Published AVES 01.05.2019
Subjects
Adenocarcinoma
Cancer treatment
Carboplatin
Chemotherapy
Death
Functional foods
Multiple organ failure
Ovarian cancer
Surgery
Textiles
Tumors
Women
Wound care
Wound healing
Germany
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Summary:Objectives: Ovarian cancer is one of the most common malignancies in women, and it is quite difficult to cure. In order to treat the disease, chemotherapy is often performed as adjuvant therapy following the surgery or neo-adjuvant cure for the pre-operative purpose. While the strategy is an effective way to destroy the tumor, it also affects healthy cells thus it causes side effects leading to even multiple organ failure and death. So that to minimize the disadvantage of chemotherapeutics, phytochemicals have been studied as chemotherapeutic agents. Curcumin is an orange-yellow nutraceutical, which is isolated from turmeric (Curcuma longa L.). This phyto-polyphenolic compound has various roles in bio-industry such as textile and food dye as well as a wide range of medicinal properties especially the anticancer feature. Methods: The aim of this study is to investigate the anti-proliferative and anti-migrative effects of curcumin on ovarian adenocarcinoma. Cell proliferation rates on ONCO-DG-1 cell line were examined in five different doses of curcumin. Wound healing assay was performed to evaluate the anti-migrative effect on curcumin on this cell line. Results: The results showed that curcumin inhibits tumor cell proliferation at 5, 10, 20, 30 and 40 [micro]M doses at 24- and 48-hours incubation time (p<0.05). IC50 dose of curcumin is determined as 17 [micro]M on ONCO-DG-1 cell line. Wound healing assays showed that curcumin inhibits the wound closure with its anti-migrative effect on ONCO-DG-1 cell line. Conclusion: Due to the anticancer features of curcumin, it can be considered as a promising chemotherapeutic agent in the treatment of ovarian adenocarcinoma. Keywords: Curcumin, Ovarian Cancer, Anticancer, Antiproliferative, Antimigrative, ONCO-DG-1
ISSN:2458-8938
DOI:10.30621/jbachs.2019.610