Synergistic antitumor effect of adenovirus-mediated hING4 gene therapy and 125I radiation therapy on pancreatic cancer

• Published in: Cancer letters Vol. 316; no. 2; pp. 211 - 218
• Main Authors: Zhao, Yaodong, Su, Chenghai, Zhai, Hongyan, Tian, Yue, Sheng, Weihua, Miao, Jingcheng, Yang, Jicheng
• Format: Journal Article
• Language: English
• Published: Clare Elsevier Ireland Ltd 28.03.2012; Elsevier Limited
• Subjects: 125I; Adenoviruses; Angiogenesis; Apoptosis; Cancer therapies; Cell culture; Cell growth; Gene therapy; ING4; Kinases; Medical prognosis; Pancreas; Pancreatic cancer; pancreatic neoplasms; prognosis; Radiation therapy; radiotherapy; Science; Signal transduction; surgery; synergism; Tumors; China; ING4; 125I; Radiation therapy; Gene therapy; Pancreatic cancer
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2011.11.003

Pancreatic cancer has a poor prognosis, even with surgery. ING4 is a member of the inhibitor of growth (ING) tumor suppressor family that has potent inhibitory effects on a variety of tumors; meanwhile, radiotherapy is a common adjunctive therapy for pancreatic cancer. Prior to this study, the effectiveness of a combination of ING4 gene-therapy and radiotherapy against pancreatic cancer had been unknown. In this study, we demonstrated that either ING4 or 125I radiotherapy treatment could induce Panc-1 pancreatic cancer cell growth suppression and apoptosis in vitro. Furthermore, both treatments inhibited tumor growth and angiogenesis of Panc-1 pancreatic cancer subcutaneously xenografted in vivo. Moreover, the combination therapy had a synergistic effect.