Spontaneous, gonadotropin-releasing hormone-induced, and progesterone-inhibited pulsatile secretion of human chorionic gonadotropin in the first trimester placenta in vitro

Using a multichannel superfusion apparatus, the secretion of human chorionic gonadotropin (hCG) was measured at 1-6 minute intervals in placental explants at 7-9 weeks of gestation. hCG was found to be secreted in distinct pulses (4-5 fold above baseline) every 11-23 minutes peak to peak. Addition o...

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Bibliographic Details
Published inThe journal of clinical endocrinology and metabolism Vol. 69; no. 1; p. 215
Main Authors Barnea, E R, Kaplan, M
Format Journal Article
LanguageEnglish
Published United States 01.07.1989
Subjects
Chorionic Gonadotropin - metabolism
Female
Gonadotropin-Releasing Hormone - analogs & derivatives
Gonadotropin-Releasing Hormone - pharmacology
Humans
In Vitro Techniques
Models, Biological
Placenta - drug effects
Placenta - secretion
Pregnancy
Pregnancy Trimester, First
Progesterone - pharmacology
Time Factors
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Summary:Using a multichannel superfusion apparatus, the secretion of human chorionic gonadotropin (hCG) was measured at 1-6 minute intervals in placental explants at 7-9 weeks of gestation. hCG was found to be secreted in distinct pulses (4-5 fold above baseline) every 11-23 minutes peak to peak. Addition of one minute pulses of GnRH analog significantly increased, whereas pulses of progesterone decreased, pulsatile hCG secretion.
ISSN:0021-972X
DOI:10.1210/jcem-69-1-215