MUC1 mucin mRNA expression in cultured human nasal and bronchial epithelial cells

The MUC1 mucin mRNA, for which the cDNA was previously cloned from human breast and pancreatic tissues, was found to be expressed in nasal and bronchial epithelial cell primary cultures from cystic fibrotic, atopic, and normal individuals. Sequence analysis of cDNA clones from the CF/T43 cystic fibr...

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Bibliographic Details
Published inAmerican journal of respiratory cell and molecular biology Vol. 6; no. 5; p. 516
Main Authors Hollingsworth, M A, Batra, S K, Qi, W N, Yankaskas, J R
Format Journal Article
LanguageEnglish
Published United States 01.05.1992
Subjects
Base Sequence
Blotting, Northern
Bronchi - physiology
Cystic Fibrosis - genetics
Epithelium - physiology
Gene Expression
Humans
In Vitro Techniques
Mucins - genetics
Nasal Mucosa - physiology
RNA, Messenger - genetics
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Summary:The MUC1 mucin mRNA, for which the cDNA was previously cloned from human breast and pancreatic tissues, was found to be expressed in nasal and bronchial epithelial cell primary cultures from cystic fibrotic, atopic, and normal individuals. Sequence analysis of cDNA clones from the CF/T43 cystic fibrosis nasal epithelial cell line revealed only insignificant differences in the 3' untranslated region of the mRNA when compared with the pancreas and breast mucin cDNAs.
ISSN:1044-1549
DOI:10.1165/ajrcmb/6.5.516