Cadmium chloride: An efficient catalyst for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones

Biginelli reaction was carried out using cadmium chloride as a catalyst to obtain the dihydropyrimidones in excellent yields. This condensation was applicable to various aldehydes with ethyl acetoacetate and urea in acetonitrile at reflux temperature.

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Bibliographic Details
Published inSynthesis (Stuttgart) no. 8; pp. 1253 - 1256
Main Authors Narsaiah, AV, Basak, AK, Nagaiah, K
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 03.06.2004
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
dihydroprimidones
cadmium chloride
DIHYDROPYRIMIDINONES
ethyl acetoacetate
BIGINELLI REACTION
BROMIDE
multicomponent reaction
CALCIUM-CHANNEL BLOCKERS
ACID-ESTERS
urea
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Summary:Biginelli reaction was carried out using cadmium chloride as a catalyst to obtain the dihydropyrimidones in excellent yields. This condensation was applicable to various aldehydes with ethyl acetoacetate and urea in acetonitrile at reflux temperature.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2004-822383