5-nitro isatin containing heterocyclics derivatives: synthesis, antioxidant activity, anticancer activity and molecular docking

The manuscript describes the synthesis of eight Novel 1,2,4-triazine and 1,2-diazino derivatives having the 5-nitro isatin moiety. Antiradical and anticancer activities were evaluated using the DPPH method and the MTT assay against breast cancer (MCF-7) cell lines. The compound with the strongest an...

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Bibliographic Details
Published inNatural product research pp. 1 - 10
Main Authors Ayad Mohamed Rasheed, Hala, Al-Majidi, Suaad M. H.
Format Journal Article
LanguageEnglish
Published 24.08.2023
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Summary:The manuscript describes the synthesis of eight Novel 1,2,4-triazine and 1,2-diazino derivatives having the 5-nitro isatin moiety. Antiradical and anticancer activities were evaluated using the DPPH method and the MTT assay against breast cancer (MCF-7) cell lines. The compound with the strongest antioxidant and anticancer properties after 24 h was compound 9 (1,2,4-triazine-3-thione) but after 48 h, compound 7 (1,2,4- triazine-3-ol) with good anticancer activity while compound 11 (1,2-diazino) after 72 h.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2023.2250898