Proconvulsant Action of Two GABAB Receptor Antagonists Is Age-Dependent

Antagonists of GABAB receptors are expected to have proconvulsant action also in developing brain. Two antagonists (CGP55845 and CGP46381) were tested in a model of cortical epileptic afterdischarges (ADs) in 12-, 18- and 25-day-old rat pups with implanted electrodes. CGP55845 was dissolved in dimet...

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Bibliographic Details
Published inPhysiological research Vol. 62; pp. S109 - S114
Main Author Mares, P
Format Journal Article
LanguageEnglish
Published Praha Institute of Physiology 2013
Subjects
Drug dosages
Electrodes
Epilepsy
Experiments
Laboratory animals
Rodents
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Summary:Antagonists of GABAB receptors are expected to have proconvulsant action also in developing brain. Two antagonists (CGP55845 and CGP46381) were tested in a model of cortical epileptic afterdischarges (ADs) in 12-, 18- and 25-day-old rat pups with implanted electrodes. CGP55845 was dissolved in dimethylsulfoxide and the results demonstrated marked proconvulsant action of this solvent which masked possible action of the antagonist. Water soluble antagonist CGP46381 led to marked potentiation of ADs in 12-day-old animals, its action decreased with age, it was negligible in 25-day-old rats. Our results demonstrated important inhibitory role of GABAB receptors at very early stages of maturation.
ISSN:0862-8408
1802-9973
DOI:10.33549/physiolres.932599