T cell receptor signaling pathways: New targets for herpes simplex virus

• Published in: Virologica Sinica Vol. 23; no. 6; pp. 429 - 437
• Main Authors: Cao, You-jia, Li, Ya-peng, Zhang, Ying-chi, Zhang, Cui-zhu
• Format: Journal Article
• Language: English
• Published: Heidelberg SP Wuhan Institute of Virology, CAS 01.12.2008; Tianjin Key Laboratory of Protein Sciences,Nankai University,Tianjin 300071,China; Department of Biochemistry and Molecular Biology,College of Life Sciences,Nankai University,Tianjin 300071,China%Tianjin Key Laboratory of Protein Sciences,Nankai University,Tianjin 300071,China; Key Laboratory of Bioactive Materials of Ministry of Education,Nankai University,Tianjin 300071,China; Department of Biochemistry and Molecular Biology,College of Life Sciences,Nankai University,Tianjin 300071,China%Key Laboratory of Bioactive Materials of Ministry of Education,Nankai University,Tianjin 300071,China
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedicine; Medical Microbiology; Microbial Genetics and Genomics; Microbiology; Oncology; Virology; Signaling; Q786; T cell receptor; Herpes simplex virus; T cell receptor,Signaling
• ISSN: 1674-0769; 1995-820X
• DOI: 10.1007/s12250-008-3000-5

Herpes simplex viruses (HSV-1 and HSV-2) cause global morbidity and synergistically correlate with HIV infection. HSV exists life-long in a latent form in sensory neurons with intermittent reactivation, in despite of host immune surveillance. While abundant evidence for HSV interfering with innate immune responses so as to favor the replication and propagation of the virus, several lines of evidence declare that HSV attenuates adaptive immunity by various mechanisms, including but not limited to the ablation of antigen presentation, induction of apoptosis, and interruption of cellular signaling. In this review, we will focus on the perturbative role of HSV in T cells signaling.