A CASE OF DRAMATICALLY IMPROVED GASTRIC CANCER RESPONDING TO TS-1/CDDP AS NEOADJUVANT CHEMOTHERAPY

A 76-year-old man with gastric cancer and the hiliar lymph node metastasis was scheduled for curative surgery. Before surgery 100 mg/day of TS-1 was orally administered for 2 weeks followed by 1 drug-free week. And 30 mg/day of CDDP was administered intravenously on days 1 and 8. The 2nd, 3rd, and 4...

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Published inNihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) Vol. 65; no. 2; pp. 375 - 379
Main Authors HORIKAWA, Masato, NAKATSUJI, Naoyuki, SUGIHARA, Seiichi, TAKAYAMA, Tomoyoshi, NOMI, Takeo, MARUYAMA, Hiroshi
Format Journal Article
LanguageEnglish
Published Japan Surgical Association 2004
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Summary:A 76-year-old man with gastric cancer and the hiliar lymph node metastasis was scheduled for curative surgery. Before surgery 100 mg/day of TS-1 was orally administered for 2 weeks followed by 1 drug-free week. And 30 mg/day of CDDP was administered intravenously on days 1 and 8. The 2nd, 3rd, and 4th courses were administered on an outpatient basis. After the treatment, abdominal CT showed a reduction in hiliar lymph node metastasis and gastric cancer with no overt serious adverse reaction. On the 15th day after 4 courses of this chemotherapy, surgery was done. Histopathological study revealed no malignant cells, and the operation was thought to result in curative resection. The patient is now healthy and free of recurrent disease 9 months after surgery. Neoadjuvant chemotherapy (TS-1/CDDP) is thus useful for the treatment of advanced gastric cancer.
ISSN:1345-2843
1882-5133
DOI:10.3919/jjsa.65.375