Role of fibroblast growth factor receptor 1 in the bone development and skeletal diseases

• Published in: Journal of Medical Colleges of PLA Vol. 22; no. 6; pp. 376 - 384
• Main Author: 李福兵 杜晓岚 陈林
• Format: Journal Article
• Language: English
• Published: State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China 01.12.2007
• Subjects: 纤维原细胞生长因子受体1; 骨生长; 骨骼疾病; bone development; fibroblast growth factor receptor 1; skeletal disease; conditional inactivation; bone fracture
• ISSN: 1000-1948
• DOI: 10.1016/S1000-1948(08)60022-2

Accumulating data suggest that FGFs/FGFR1 plays essential roles in the bone development and human skeletal diseases. Conditional inactivation of fgfrl caused different phenotypes displaying in different cells or specific organs and revealed some novel functions of FGFR1 in bone development. Fgfrl mutation mainly induced 2 types of human skeletal diseases, craniosynostosis syndrome and dysplasias. Similar mutation of fgfrl in mouse model just mimicked the phenotype that happened in human. These fa- cilitate the investigation on the underlying mechanism of the diseases. Here we mainly focused on the ad- vance of FGFR1 function in the bone development and its mutation caused skeletal diseases.