Meta-analysis study of small extracellular vesicle nursing application therapies for healing of wounds and skin regeneration
We designed and performed this meta-analysis to investigate the impact of the application of extracellular small vesicle therapies on regeneration of skin and wound healing. The findings of this study were computed using fixed or random effect models. The mean differences (MDs), and odds ratio (ORs)...
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Published in | Archives of dermatological research Vol. 316; no. 7; p. 346 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
07.06.2024
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | We designed and performed this meta-analysis to investigate the impact of the application of extracellular small vesicle therapies on regeneration of skin and wound healing. The findings of this study were computed using fixed or random effect models. The mean differences (MDs), and odds ratio (ORs) with their 95% confidence intervals (CIs) were calculated. In this study, 43 publications were included, encompassing 530 animals with artificial wounds. Small extracellular vesicle therapy had a significant greater rate of wound closure (MD, 24.0; 95% CI, 19.98–28.02, P < 0.001), lower scar width (MD, −191.33; 95%CI, −292.26–−90.4, P < 0.001), and higher blood vessel density (MD,36.11; 95%CI, 19.02–53.20, P < 0.001) compared to placebo. Our data revealed that small extracellular vesicle therapy had a significantly higher regeneration of skin and healing of wounds based on the results of wound closure rate, lower scar width, and higher blood vessel density compared to placebo. Future studies with larger sample size are needed. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
ISSN: | 1432-069X 0340-3696 1432-069X |
DOI: | 10.1007/s00403-024-02992-4 |