Exosomes Derived from Mesenchymal Stem Cells: Therapeutic Opportunities for Spinal Cord Injury

Spinal cord injury (SCI) is a serious neurological condition comprising primary and secondary injury and causing severe neurological impairments. The effect of the conventional treatment is limited, including supportive therapy and emergency surgery. Exosomes derived from mesenchymal stem cells (MSC...

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Bibliographic Details
Published inBulletin of experimental biology and medicine Vol. 176; no. 6; pp. 716 - 721
Main Author Zhang, C.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.04.2024
Springer Nature B.V
Subjects
Apoptosis
Biomedical and Life Sciences
Biomedicine
Bone marrow
Cell Biology
Exosomes
Genotype & phenotype
Inflammation
Internal Medicine
Laboratory Medicine
Mesenchymal stem cells
MicroRNAs
Pathology
Proteins
Spinal cord injuries
Stem cell transplantation
Stem cells
Trauma
spinal cord injury
drug delivery vehicle
exosomes
mesenchymal stem cells
cell therapy
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Summary:Spinal cord injury (SCI) is a serious neurological condition comprising primary and secondary injury and causing severe neurological impairments. The effect of the conventional treatment is limited, including supportive therapy and emergency surgery. Exosomes derived from mesenchymal stem cells (MSCs-Exos) were previously reported to exert its potential therapeutic effects on SCI. Compared with mesenchymal stem cells (MSCs) transplantation for SCI, MSC-Exos showed several superiorities. In the present review, we summarized the revealed data of mechanisms underlying MSC-Exos repairing of SCI and discussed the issues of MSC-Exos use. Thus, in this review we summarized the latest studies on MSCs-Exos in the therapy of SCI and discussed whether MSCs-Exos can be applied to SCI and the prospects of transformation application.
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ISSN:0007-4888
1573-8221
1573-8221
DOI:10.1007/s10517-024-06095-y