Reconstructing developmental landscapes and trajectories from single-cell data

With the advent of high-throughput single-cell measurement technologies, the daunting prospect of charting Waddington's landscape is coming within reach. This holds tremendous potential for futuristic applications including regenerative medicine. Here, we review recent theoretical and methodolo...

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Bibliographic Details
Published inCurrent opinion in systems biology Vol. 27; p. 100351
Main Author Schiebinger, Geoffrey
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.09.2021
Subjects
Developmental landscapes
Optimal transport
Single-cell analysis
Stochastic processes
Trajectory inference
Trajectory inference
Single-cell analysis
Developmental landscapes
Optimal transport
Stochastic processes
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Summary:With the advent of high-throughput single-cell measurement technologies, the daunting prospect of charting Waddington's landscape is coming within reach. This holds tremendous potential for futuristic applications including regenerative medicine. Here, we review recent theoretical and methodological developments in reconstructing developmental landscapes and trajectories from single-cell data.
ISSN:2452-3100
2452-3100
DOI:10.1016/j.coisb.2021.06.002