Fabrication of CuNPs Using Schiff Base Ligand and Their Catalytic Reduction of Pharmaceutical Drugs, Fluorescence Selective Detection of Cd2+, Antimicrobial, and Antioxidant Activities

• Published in: Journal of fluorescence Vol. 34; no. 3; pp. 1307 - 1318
• Main Authors: Suneetha, G., Ayodhya, Dasari, Srikanth, K., Manjari, P. Sunitha
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.05.2024; Springer Nature B.V
• Subjects: Absorption spectroscopy; Analytical Chemistry; Antioxidants; Biochemistry; Biological and Medical Physics; Biomedical and Life Sciences; Biomedicine; Biophysics; Biotechnology; Cadmium; Chemical reduction; Chemical synthesis; Drugs; Fourier transforms; Free radicals; Functional groups; Imines; Infrared analysis; Infrared spectroscopy; Pharmaceuticals; Reaction kinetics; Scavenging; Spectrum analysis; Cd; DPPH scavenging; detection; Schiff base-CuNPs; Capecitabine; Antimicrobial potential; Ciprofloxacin
• ISSN: 1053-0509; 1573-4994
• DOI: 10.1007/s10895-023-03342-9

Here, we have approached the synthesis of copper nanoparticles (CuNPs) Schiff base (5-trifluoromethoxy-2-(((2chloro-5-(methyl)phenyl)imino)methyl)phenol)). The synthesized CuNPs were characterized by UV–vis spectroscopy, PL, FTIR, powder XRD, and TEM analysis. From the UV-vis absorption spectroscopy, an absorption peak was observed at 585 nm. As a result of the powder XRD and TEM studies, spherical particle sizes ranged between 4 and 10 nm. FT-IR analysis confirmed the presence of functional groups ‒OH, C=C, -C=N-, and C‒H triggers the synthesis of CuNPs. Further, the catalytic property of the CuNPs were revealed by the degradation of pharmaceutical drugs such as Capecitabine (CAP) and Ciprofloxacin (CIP) in 90 min of reaction time in the presence of NaBH 4 . The reaction kinetics followed pseudo-first-order with k-values (rate constant) 0.248 min -1 and 0.307 min −1 . In addition, the synthesized CuNPs have exhibited selective sensing detection of Cd 2+ metal ions in different range of concentration (10-100 µM) by spectrofluorometrically with the limit of detection (LOD) is 0.0284 nM and limit of quantification (LOQ) is 0.0586 nM. The CuNPs revealed significant antioxidant activities against DPPH as a common free radical at 50 µg/mL with 71.24% of scavenging activity. The maximum antimicrobial potential and zone of inhibition of P. Aeruginosa is 17.25±0.8 mm and A. niger is 12.1 mm by using CuNPs.