Esculentoside a Prevents Cell Damage Induced by Carbapenem-Resistant Klebsiella Pneumoniae Infection

We have investigated the role of Esculentoside A in the progression of carbapenem-resistant Klebsiella pneumoniae infection in Human MLE-12 cells. The results of the studies show that Esculentoside A enhances the viability of carbapenem-resistant Klebsiella pneumoniae-infected MLE-12 cells and suppr...

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Published inCurrent topics in nutraceuticals research Vol. 21; no. 4; pp. 332 - 338
Main Authors Xu, Ya, Zhang, Hong, Xu, Linlin, Sun, Yang, Shi, Chunlei, Gao, Wen, Xu, Junwen, Shao, Keke
Format Journal Article
LanguageEnglish
Published New Century Health Publishers, LLC 01.11.2023
Subjects
Albumin
Antibodies
Apoptosis
Bacterial pneumonia
Health aspects
Interleukins
Kidney diseases
Mitogens
Pneumonia
Proteases
Protein kinases
Viral antibodies
China
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Summary:We have investigated the role of Esculentoside A in the progression of carbapenem-resistant Klebsiella pneumoniae infection in Human MLE-12 cells. The results of the studies show that Esculentoside A enhances the viability of carbapenem-resistant Klebsiella pneumoniae-infected MLE-12 cells and suppresses cell apoptosis. EsA also suppresses mitochondrial damage and oxidative stress in lung epithelial cells caused by carbapenem-resistant Klebsiella pneumoniae infections. The data further confirmed that Esculentoside A could relieve mitochondrial damage, apoptosis, and oxidative stress in carbapenem-resistant Klebsiella pneumonia-infected lung epithelial cells by regulating the mitogen-activated protein kinase pathway.
ISSN:1540-7535
2641-452X
DOI:10.37290/ctnr2641-452X.21:332-338